Random Mutation Quotes

Dawkins mentioned two mechanisms: the theory of the 'primeval soup' and the Cairns-Smith theory. He discussed the latter in some detail. Since no one has computed, for either theory, the chances of the events occurring, Dawkins could not tell us what those chances are. The mechanisms of both theories, however, have every appearance of being very improbably – even to the point of being impossible. ~ Lee Spetner

Although random mutations influenced the course of evolution, their influence was mainly by loss, alteration, and refinement ... Never, however, did that one mutation make a wing, a fruit, a woody stem, or a claw appear. Mutations, in summary, tend to induce sickness, death, or deficiencies. No evidence in the vast literature of heredity changes shows unambiguous evidence that random mutation itself, even with geographical isolation of populations, leads to speciation. ~ Lynn Margulis

Don't get me wrong. I'm not recommending one form of love over another. I don't know if prudent or reckless love is the better, monied or penniless love the surer, heterosexual or homosexual love the sexier, married or unmarried love the stronger. I may be tempted towards didacticism, but this isn't an advice column. I can't tell you whether or not you're in love. If you need ask, then you probably aren't, that's my only advice… But I can tell you why to love. Because the history of the world, which only stops at the half-house of love to bulldoze it into rubble, is ridiculous without it. The history of the world becomes brutally self-important without love. Our random mutation is essential because it is unnecessary. Love won't change the history of the world (that nonsense about Cleopatra's nose is strictly for sentimentalists), but it will do something much more important: teach us to stand up to history, to ignore its chin-out strut. I don't accept your terms, love says; sorry, you don't impress, and by the way what a silly uniform you're wearing. Of course, we don't fall in love to help out with the world's ego problem; yet this is one of love's surer effects.'
Love and truth, that's the vital connection, love and truth. [. . .] How you cuddle in the dark governs how you see the history of the world. ~ Julian Barnes

Once, on a walk by a river- Eskdale in low reddish sunlight, with a dusting of snow- his daughter quoted to him an opening verse by her favourite poet. Apparently, not many young women loved Phillip Larkin the way she did. 'If I were to construct a religion/ I should make use of water.' She said she liked the laconic use of 'called in'- as if he would be, as if anyone ever is. They stopped to drink coffee from a flask, and Perowne, tracing a line of lichen with a finger, said that if he ever got the call, he'd make us of evolution. What better creation myth? An unimaginable sweep of time, numberless generations spawning by infinitesimal steps complex living beauty out of inert matter, driven on by the blind furies of random mutation, natural selection and environmental change, with the tragedy of forms continually dying, and lately the wonder of minds emerging and with them morality, love, art, cities- and the unprecedented bonus of this story happening to be demonstrably true. ~ Ian McEwan

To understand Darwin's work, you have to distinguish between his theory of descent and his theory of natural selection. THe full name of the first is the theory of descent with modification. Some call it the fact of evolution, and some call it the doctrine of evolution. ~ Lee Spetner

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria's effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What's more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so. ~ Michael J. Behe

We are surrounded by the absurd excess of the universe. By meaningless bulk, vastness without size, power without consequence. The stubborn iteration that is present without being felt. Nothing the spirit can marry. Merely phenomenon and its physics. An endless, endless of going on. No habitat where the brain can recognize itself. No pertinence for the heart. Helpless duplication. ~ Jack Gilbert

Verbal arguments should always be suspect. ~ Lee Spetner

Neo-Darwinians do cite some examples of evolution they claim the NDT explains. Natural selection can indeed account for the replacement of light-colored moths with dark ones when the lichens get covered with soot. But no one has shown that the difference between the two kinds of moths arose by a random mutation. The key point of randomness is not tested by those data. ~ Lee Spetner

Nothing in Nature is random. A thing appears random only through the incompleteness of our knowledge. ~ Baruch Spinoza

I understood that he did not see the person he was talking to. He had the drifter's inclination to be impervious to names and faces. These were interchangeable components room to room, country to country. He did not talk so much as narrate. He traced a wavy line, his, and there was usually someone willing to be the random body that he told his stories to. ~ Don DeLillo

I think nobody would claim that random genetic drift is capable of producing adaptation, that is to say the illusion of design. Random genetic drift can't produce wings that are good at flying, or eyes that are good at seeing, or legs that are good at running. But random genetic drift probably is very important in driving evolution at the molecular genetic level. ~ Richard Dawkins

The important question is, what will your wear for a wedding dress, Alexia? You look horrible in white. ~ Gail Carriger

That which is static and repetitive is boring. That which is dynamic and random is confusing. In between lies art. ~ John Locke

History was indeed controlled by blind forces, as well as character and courage and treachery and love. And accident and random chance. And stray bullets and telegrams and tips. And cats. ~ Connie Willis

While it is certainly true that God's love for us does not protect us from pain and sorrow, it is also true that all occasions of pain and sorrow are under the absolute control of God. If God controls the circumstances of the sparrow, how much more does He control the circumstances that affect us? God does not walk away and leave us to the mercy of uncontrolled random or chance events. ~ Jerry Bridges

To embrace the belief that man is the accidental product of a random and otherwise genetically and biologically impossible Darwinian gradual evolution allegedly monitored by a quasi-fictitious natural selection, a process that supposedly started with an amoeba nobody knows how it arrived on Earth that somehow became a fish with stumps for legs that turned crocodile, a creature that following successive transmutations "evolved" into an ape that ended up as Leonardo Da Vinci is an attitude that comes in conflict with the scientific method of research and it certainly violates its standard principles. ~ Paul Greene

To say the Israelis were caught off guard was like saying the Great Wall of China is long" is not just a random bad sentence, it's LaHaye and Jenkins's idea of Pulitzer-winning prose. ~ Daniel Radosh

I love the fashion which is out of fashion. ~ Megha Khare

As Atwood concludes after a random and informal sampling, men and women differ markedly in the 'scope of their threatenability': 'Why do men feel threatened by woman?' I asked a male friend of mine ... '[M]en are bigger, most of the time ... and they have on the average a lot more money and power.' 'They're afraid women will laugh at them,' he said. 'Undercut their world view.' Then I asked some women students in a quickie poetry seminar I was giving, 'Why do women feel threatened by men?' 'They're afraid of being killed,' they said'. ~ Shuli Barzilai

Love is random; fear is inevitable. ~ Orson Scott Card

A dictionary resembles the world more than a novel does, because the world is not a coherent sequence of actions but a constellation of things perceived. It is looked at, unrelated things congregate, and geographic proximity gives them meaning. If events follow each other, they are believed to be a story. But in a dictionary, time doesn't exist: ABC is neither more nor less chronological than BCA. To portray your life in order would be absurd: I remember you at random. My brain resurrects you through stochastic details, like picking marbles out of a bag. ~ Edouard Leve

I believe in love at first sight. Fate, the universe, all of it. But not how you're thinking. I don't mean it in the 'our souls were split and you're my other half forever and ever' sort of way. I just think you're mean to meet some people. I think the universe nudges them into your path. Even on random Monday afternoons in July. Even at the post office. ~ Becky Albertalli

Open a dictionary at random; metaphors fill every page. Take the word "fathom." for example. The meaning is clear. A fathom is a measurement of water depth, equivalent to about six feet. But fathom also means "to understand." Why?

Scrabble around in the word's etymological roots. "Fathom comes from the Anglo-Saxon faethm, meaning "the two arms outstretched." The term was originally used as a measurement of cloth, because the distance from fingertip to fingertip for the average man with his arms outsretched is roughly six feet. This technique was later extended to sounding the depths of bodies of water, since it was easy to lower a cord divided into six-foot increments, or fathoms, over the side of a boat. But how did fathom come to mean "to understand," as in "I can't fathom that" or "She's unfathomable"? Metaphorically, of course.

You master something- you learn to control or accept it-when you embrace it, when you get your arms around it, when you take it in hand. You comprehend something when you grasp it, take its measure, get to the bottom of it-fathom it.

Fathom took on its present significance in classic Aristotelian fashion: through the metaphorical transfer of its original meaning (a measurement of cloth or water) to an abstract concept (understanding). This is the primary purpose of metaphor: to carry over existing names or descriptions to things that are either so new that they haven't yet been named or so abstract that they cannot ~ James Geary

It's not a random chance that we have Alanis Morissette. She didn't evolve out of a null and void. She came from a former template. She borrowed styles and sounds from a very limited set of other artists. ~ Greg Graffin

Stuff Happens.' That's the G-rated version. That's a bumper sticker that
only a straight white upper middle class male could have made. Because anyone who
isn't straight, anyone who isn't male, anyone who isn't white, anyone who isn't upper middle class knows that stuff doesn't just happen. Stuff gets done by people to people. Nothing is a coincidence. Nothing is random. This isn't osmosis. And so we act as if it's this passive thing, but yet that's not the case. ~ Tim Wise

I thought I should call a matchmaker.

For me, this seemed like a radical step. It never occurred to me to hire a matchmaker when I was younger because I always believed I'd meet a man on my own. He'd be sitting next to me on an airplane, waiting in line behind me at the dry cleaner, working in the same office attending the same party, hanging out at the same coffeehouse.

It seemed ridiculous now, when I thought about the odds of this happening. After all, we don't subject other important aspects of out lives to pure chance. When you want to get a job you don't just hang out in the lobbies of office buildings, hoping an employer will strike up a conversation with you. When you want to buy a house, you don't walk aimlessly from neighborhood to neighborhood on your own, hoping to spot a house that happens to be for sale, matches your personal taste and contains the appropriate number of bedrooms and bathrooms. That's too random. If that's your only method of house hunting, you might end up homeless. So you hire a real estate broker to show you the potential homes that meet your needs. By the same token, why not hire a matchmaker to show you potential partners? ~ Lori Gottlieb

Go boldly forth, my simple lay,Whose accents flow with artless ease,Like orient pearls at random strung. ~ William Jones

Random thoughts that fly away.
Where words has no place to stay.
Let it be right where they are.
Let the work of art preserve its life. ~ Diana Rose Morcilla

It is our custom to say that someone is 'lucky' or 'unlucky' if they meet with fortunate or unfortunate circumstances, respectively. It is, however, too simplistic to think in terms of random 'luck.' Even from a scientific point of view, this is not a sufficient explanation. ~ Dalai Lama

Love of my life. Love. Of. My. Life. A retrospectively absurd concept since the most I can say is that he was the love of a particular period of my life, and that it is the random vagaries of life itself, and never love, that define time limits. Meaning, to be in love and wish for its immortality is energy unwisely spent. The idea that we have any choice in the matter is the great illusion. ~ Luke Davies

No matter who I couldn't save before, no matter if I'm stuck being a random mess of a girl, I'm still going to save something. ~ Sarah Porter

Horses (thou say'st) and asses men may try,
And ring suspected vessels ere they buy;
But wives, a random choice, untried they take;
They dream in courtship, but in wedlock wake;
Then, nor till then, the veil's removed away,
And all the woman glares in open day. ~ Alexander Pope

The name America has definitely grown on me. I wish there was a big patriotic story behind it, but the truth is that my grandfather was a librarian who knew all sorts of random facts. ~ America Ferrera

Breakfast is a personal ritual that can only be properly observed alone, and in a spirit of genuine excess. The food factor should always be massive: four Bloody Marys, two grapefruits, a pot of coffee, Rangoon crepes, a half-pound of either sausage, bacon, or corned beef hash with diced chiles, a Spanish omelette or eggs Benedict, a quart of milk, a chopped lemon for random seasoning, and something like a slice of Key lime pie, two margaritas, and six lines of the best cocaine for dessert. ~ Hunter S. Thompson

We find in the history of ideas mutations which do not seem to correspond to any obvious need, and at first sight appear as mere playful whimsies such as Apollonius' work on conic sections, or the non-Euclidean geometries, whose practical value became apparent only later. ~ Arthur Koestler

Moving forward will not be for the faint of heart. But if the next century witnesses failure, let it be because our science is not yet up to the job, not because we don't have the courage to make less random the sometimes most unfair courses of human evolution. ~ James D. Watson

It uses the greatest random-access indexing system ever invented - one that computer scientists haven't come even close to replicating. Whereas an index in the back of a book provides a single address - a page number - for each important subject, each subject in the brain has hundreds if not thousands of addresses. Our internal memories are associational, nonlinear. You don't need to know where a particular memory is stored in order to find it. It simply turns up - or doesn't - when you need it. Because of the dense network that interconnects our memories, we can skip around from memory to memory and idea to idea very rapidly. ~ Joshua Foer

You know what's fun? You pick somebody at random, like out of the phone book, and send them about 100 'Just Because' cards. They can't even ask you why you did it. ~ Brian Regan

I think I'm different. I've got alpha, baby ... I think I can find the profits of surprise, the yield of real knowledge. Everyone says that, of course, but most investors are all beta
just volatility, just the random motion of the surf ... they get killed. To generate alpha, I need help, direction, signposts, analysts, and sometimes even brandy-toting salesmen. ~ George Gilder

Bad luck was merely a random occurrence that didn't go in one's favor. ~ Kresley Cole

We are born by accident into a purely random universe. ~ Robert Silverberg

Marked." My face was on fire, my limbs shaking. "All of you. I will take all of you out with my own bare hands!"
There was laughter building in Bram's voice as he responded. "As cute as I'm sure that would be, your attempt ... if we thought the people who might try to trace that chip could make you absolutely, one hundred percent safe, I would carry you to them and hand you over myself."
I gingerly rested my fingertips against my forehead, breathing deeply, trying to calm myself down.
"There are some very bad men out to get you, Miss Dearly."
"You have got to be kidding me."
"By the way, you have quite the vocabulary, for a princess." He still sounded amused.
This statement was random enough to get my attention. "Princess?" I asked, confused.
"You know, a princess. A New Victorian girl."
My lips parted to fire off another question before it clicked. "You're a Punk."
"Born and bred."
"Fantastic. ~ Lia Habel

Careless of books, yet having felt the power
Of Nature, by the gentle agency
Of natural objects, led me on to feel
For passions that were not my own, and think
(At random and imperfectly indeed)
On man, the heart of man, and human life. ~ William Wordsworth

Variation must be taken as random until there is positive evidence to the contrary. ~ Harold Jeffreys

People just want to believe. Otherwise they would have to admit that life is just a random series of good and bad things that happen until one day you die. ~ Nicola Yoon

As soon as we cease to pry about at random, we shall come to rely upon accredited bodies of authoritative dogma; and as soon as we come to rely upon accredited bodies of authoritative dogma, not only are the days of our liberty over, but we have lost the password that has hitherto opened to us the gates of success as well. ~ Learned Hand

But remember that reading provides nourishment for hungers we might not even be aware of. How often have I chosen a book at random and found in it an answer I didn't realize I was seeking. ~ Beth Ann Fennelly

The universe was not kind to auggie pullman. what did the little kid ever do to deserve his sentence? what did the parents do? or olivia? she once mentioned that some doctor told her parents that he odds of someone getting the same combination of syndromes that came together to make auggie's face was like one in four million. so doesn't that make the universe a giant lottery, then? you purchase a ticket when you're born. it's all just random whether you get a good ticket or a bad ticket. it's all just luck. ~ R.J. Palacio

Random acts of kindness, however small it may be can transform the world. ~ Amit Ray

It is because the human spirit knows, deep down, that all lives intersect. That death doesn't just take someone, it misses someone else, and in the small distance between being taken and being missed, lives are changed."
" ... We think such thngs are random. But there is a balance to it all. One withers, another grows. Birth and death are part of a whole." "It is why we are drawn to babies ... " "And to funerals. ~ Mitch Albom

When Johnny Depp saw it, he was so excited he fluffed up to twice his normal size. ~ Diane Messidoro

With worms you can just change genes at random and see if you can find a mutant that does what you want it to do. ~ Cynthia Kenyon

I don't write a great song every day. I don't write a great song every couple weeks. It comes in such random times. ~ Macklemore

The location of Giza and more specifically that of the Great Pyramid is not random in reference to the three only holy sites of Islam. The lunar year's quantity itself was encoded therein. ~ Ibrahim Ibrahim