Jacques Monod Quotes

Nécessité absolue trouver origine de cet emmerdement [It is absolutely necessary to find the origin of this pain in the ass]. - Jacques Monod ~ Siddhartha Mukherjee

Armed with all the powers, enjoying all the wealth they owe to science, our societies are still trying to practice and to teach systems of values already destroyed at the roots by that very science. Man knows at last that he is alone in the indifferent immensity of the universe, whence which he has emerged by chance. His duty, like his fate, is written nowhere. ~ Jacques Monod

Chance alone is at the source of all novelty, all creation in the biosphere. ~ Jacques Monod

The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought. ~ Max F. Perutz

In science, self-satisfaction is death. Personal self-satisfaction is the death of the scientist. Collective self-satisfaction is the death of the research. It is restlessness, anxiety, dissatisfaction, agony of mind that nourish science. ~ Jacques Monod

There are living systems; there is no living "matter." No substance, no single molecule, extracted and isolated from a living being possess, of its own, the aforementioned paradoxical properties. They are present in living systems only; that is to say, nowhere below the level of the cell. ~ Jacques Monod

Every living being is also a fossil. Within it, all the way down to the microscopic structure of its proteins, it bears the traces if not the stigmata of its ancestry. ~ Jacques Monod

It necessarily follows that chance alone is at the source of every innovation, and of all creation in the biosphere. Pure chance, absolutely free but blind, at the very root of the stupendous edifice of evolution: this central concept of modern biology is no longer one among many other possible or even conceivable hypotheses. It is today the sole conceivable hypothesis, the only one that squares with observed and tested fact. And nothing warrants the supposition - or the hope - that on this score our position is ever likely to be revised. There is no scientific concept, in any of the sciences, more destructive of anthropocentrism than this one. ~ Jacques Monod

Man's destiny is nowhere spelled out, nor is his duty. ~ Jacques Monod

All religions, nearly all philosophies, and even a part of science testify to the unwearying, heroic effort of mankind desperately denying its contingency. ~ Jacques Monod

Chance and necessity. ~ Jacques Monod

Another curious aspect of the theory of evolution is that everybody thinks he understands it. I mean philosophers, social scientists, and so on. While in fact very few people understand it, actually, as it stands, even as it stood when Darwin expressed it, and even less as we now may be able to understand it in biology. ~ Jacques Monod

A totally blind process can by definition lead to anything; it can even lead to vision itself. ~ Jacques Monod

Everything comes from experience; yet not from actual experience, reiterated by each individual with each generation, but instead from experience accumulated by the entire ancestry of the species in the course of its evolution. ~ Jacques Monod

Among all the occurrences possible in the universe the a priori probability of any particular one of them verges upon zero. Yet the universe exists; particular events must take place in it, the probability of which (before the event) was infinitesimal. At the present time we have no legitimate grounds for either asserting or denying that life got off to but a single start on earth, and that, as a consequence, before it appeared its chances of occurring were next to nil ... Destiny is written concurrently with the event, not prior to it ... The universe was not pregnant with life nor the biosphere with man. Our number came up in the Monte Carlo game. Is it surprising that, like the person who has just made a million at the casino, we should feel strange and a little unreal? ~ Jacques Monod

One may well find oneself beginning to doubt whether all this could conceivably be the product of an enormous lottery presided over by natural selection, blindly picking the rare winners from among numbers drawn at utter random ... nevertheless although the miracle of life stands "explained" it does not strike us as any less miraculous. As Francois Mauriac wrote, What this professor says is far more incredible than what we poor Christians believe. ~ Jacques Monod

Even today a good many distinguished minds seem unable to accept or even to understand that from a source of noise natural selection alone and unaided could have drawn all the music of the biosphere. In effect natural selection operates upon the products of chance and can feed nowhere else; but it operates in a domain of very demanding conditions, and from this domain chance is barred. It is not to chance but to these conditions that evolution owes its generally progressive course, its successive conquests, and the impression it gives of a smooth and steady unfolding. ~ Jacques Monod

One of the great problems of philosophy, is the relationship between the realm of knowledge and the realm of values. Knowledge is what is; values are what ought to be. I would say that all traditional philosophies up to and including Marxism have tried to derive the 'ought' from the 'is.' My point of view is that this is impossible, this is a farce. ~ Jacques Monod

The ancient covenant is in pieces; man knows at last that he is alone in the universe's unfeeling immensity, out of which he emerged only by chance. His destiny is nowhere spelled out, nor is his duty. The kingdom above or the darkness below: it is for him to choose. ~ Jacques Monod

I became fascinated by the then-blossoming science of molecular biology when, in my senior year, I happened to read the papers by Francois Jacob and Jacques Monod on the operon theory. ~ Susumu Tonegawa

A curious aspect of the theory of evolution is that everybody thinks he understands it. ~ Jacques Monod

The scientific attitude implies what I call the postulate of objectivity - that is to say, the fundamental postulate that there is no plan, that there is no intention in the universe. Now, this is basically incompatible with virtually all the religious or metaphysical systems whatever, all of which try to show that there is some sort of harmony between man and the universe and that man is a product - predictable if not indispensable - of the evolution of the universe. ~ Jacques Monod

What is true for E. coli is also true for the elephant. ~ Jacques Monod

Chance alone is at the source of every innovaton, of all creation in the biosphere. Pure chance, only chance, absolute but blind liberty is at the root of the prodigious edifice that is evolution ... It today is the sole conceivable hypothesis, the only one that squares with observed and tested fact. Stating life began by the chance collision of particles of nucleic acid in the "prebiotic soup." ~ Jacques Monod

Jacques La Borwitz had his points, no doubt, but so have the sub-microscopic protozoa, so has a dog prowling for a bitch and a bone." -Cecelia Brady ~ F Scott Fitzgerald

No aquarium, no tank in a marine land, however spacious it may be, can begin to duplicate the conditions of the sea. And no dolphin who inhabits one of those aquariums or one of those marine lands can be considered normal. ~ Jacques-Yves Cousteau

Thus engaged, with her right elbow supported by her left hand, Madame Defarge said nothing when her lord came in, but coughed just one grain of cough. This, in combination with the lifting of her darkly defined eyebrows over her toothpick by the breadth of a line, suggested to her husband that he would do well to look round the shop among the customers, for any new customer who had dropped in while he stepped over the way.

The wine-shop keeper accordingly rolled his eyes about, until they rested upon an elderly gentleman and a young lady, who were seated in a corner. Other company were there: two playing cards, two playing dominoes, three standing by the counter lengthening out a short supply of wine. As he passed behind the counter, he took notice that the elderly gentleman said in a look to the young lady, "This is our man."

"What the devil do you do in that galley there?" said Monsieur Defarge to himself; "I don't know you."

But, he feigned not to notice the two strangers, and fell into discourse with the triumvirate of customers who were drinking at the counter.

"How goes it, Jacques?" said one of these three to Monsieur Defarge. "Is all the spilt wine swallowed?"

"Every drop, Jacques," answered Monsieur Defarge.

When this interchange of Christian name was effected, Madame Defarge, picking her teeth with her toothpick, coughed another grain of cough, and raised her eyebrows by the breadth of another line.Charles Dickens