Alterations Quotes

Every fundamental order is a spatial order. One speaks of the constitution of a country or a piece of earth as of its fundamental order, its Nomos. Now, the true, actual fundamental order touches in its essential core upon particular spatial boundaries and separations, upon particular quantities and a particular partition of the earth. At the beginning of every great epoch there stands a great land-appropriation. In particular, every significant alteration and every resituating of the image of the earth is bound up with world-political alterations and with a new division of the earth, with a new land-appropriation. ~ Carl Schmitt

A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here. ~ Francis Crick

Incidental by-products of alterations in other traits? Belyaev strongly leaned toward the latter view, because of a phenomenon known as "pleiotropy": a single gene affecting multiple traits. Pleiotropy means that selection - whether natural or artificial - for one trait can affect many others. This is why evolutionary biologists make a distinction between selection for and selection of.9 ~ Anonymous

But if humans can make new varieties of plants and animals, must not nature do so also? This related process is called natural selection. That life has changed fundamentally over the aeons is entirely clear from the alterations we have made in the beasts and vegetables during the short tenure of humans on Earth, and from the fossil evidence. ~ Carl Sagan

We are rendering many species extinct; we may even succeed in destroying ourselves. But this is nothing new for the Earth. Humans would then be just the latest in a long sequence of upstart species that arrive on-stage, make some alterations in the scenery, kill off some of the cast, and then themselves exit stage-left forever. New players appear in the next act. The Earth abides. It has seen all this before. ~ Carl Sagan

The people of Canada do not wish as a result of mass immigration to make a fundamental alteration in the character of our population. Large scale immigration from the Orient would change the fundamental composition of the Canadian population. ~ William Lyon Mackenzie King

For my part I consider the earth very noble and admirable precisely because of the diverse alterations, changes, generations, etc. that occur in it incessantly. ~ Galileo Galilei

Research from these new disciplines has revealed that trauma produces actual physiological changes, including a recalibration of the brain's alarm system, an increase in stress hormone activity, and alterations in the system that filters relevant information from irrelevant. We now know that trauma compromises the brain area that communicates the physical, embodied feeling of being alive. These changes explain why traumatized individuals become hypervigilant to threat at the expense of spontaneously engaging in their day-to-day lives. They also help us understand why traumatized people so often keep repeating the same problems and have such trouble learning from experience. We now know that their behaviors are not the result of moral failings or signs of lack of willpower or bad character - they are caused by actual changes in the brain. This ~ Bessel A. Van Der Kolk

Altogether, these observations suggest that several processes contribute to psychotic experience: the loss of familiarity with the world, hypothetically associated with noisy information processing; increased novelty detection mediated by the hippocampus; associated alterations of prefrontal cortical processing, which have reliably been associated with impairments in working memory and other executive functions; increased top-down effects of prior beliefs mediated by the frontal cortex that may reflect compensatory efforts to cope with an increasingly complex and unfamiliar world; and finally disinhibition of subcortical dopaminergic neurotransmission, which increases salience attribution to otherwise irrelevant stimuli. Furthermore, increased noise of chaotic or stress-dependent dopamine firing can reduce the encoding of errors of reward prediction elicited by primary and secondary reinforcers, thus contributing to a subjective focusing of attention on apparently novel and mysterious environmental cues while reducing attention and motivation elicited by common and natural and social stimuli. ~ Andreas Heinz

There are two processes which we adopt consciously or unconsciously when we try to prophesy. We can seek a period in the past whose conditions resemble as closely as possible those of our day, and presume that the sequel to that period will, save for some minor alterations, be similar. Secondly, we can survey the general course of development in our immediate past, and endeavor to prolong it into the near future. The first is the method the historian; the second that of the scientist. Only the second is open to us now, and this only in a partial sphere. ~ Winston Churchill

What was true love, anyway? What did the fabric of it feel like? Rough? Smooth? Velvety soft? Would she recognize it immediately, or would she have to browse awhile? Would true love fit her perfectly or be like a store-bought gown in need a alterations? ~ Andrea Boeshaar

Both for the production on a mass scale of this communist consciousness, and for the success of the cause itself, the alteration of men on a mass scale is necessary, an alteration which can only take place in a practical movement, a revolution; this revolution is necessary, therefore, not only because the ruling class cannot be overthrown in any other way, but also because the class overthrowing it can only in a revolution succeed in ridding itself of all the muck of ages and become fitted to found society anew. ~ Karl Marx

The relationships among natural and drug-induced alterations of consciousness must be understood from an evolutionary perspective. This reveals altered consciousness to be related to endogenous mechanism, which are triggered by both ancient evolutionary adaptations and more recently acquired propensities to use exogenous sources of substances to alter consciousness. ~ John Rush

It is as though the practices organizing a bustling city were characterized by [city practitioners', everyday citizens'] blindness. The neworks of these moving, intersecting writings compose a manifold story that has neither author nor spectator, shaped out of fragments of trajectories and alterations of spaces: in relation to representations, it remains daily and indefinitely other. ~ Michel De Certeau

How to achieve such anomalies, such alterations and re-fashionings of reality so what comes out of it are lies, if you like, but lies that are more than literal truth. ~ Vincent Van Gogh

Those who sniff decay in every shift of sense or alteration of usage do the language no service. Too often for such people the notion of good English has less to do with expressing ideas clearly than with making words conform to some arbitrary pattern. ~ Bill Bryson

We began reading books together. He loved Dr. Seuss. I read those books so often I could turn the pages and say the words from memory. I became bored with repetition, and I began to make subtle alterations. The story turned into:
One fish
Two fish
Black fish
Blue fish
I eat you fish
And:
See them all
See them run
The man in back
He has a gun ~ John Elder Robison

Our belief in salvation through the market is very much in the Utopian tradition. The economists and managers are the servants of God. Like the medieval scholastics, their only job is to uncover the divine plan. They could never create or stop it. At most they might aspire to small alterations. ~ John Ralston Saul

Addiction isn't about substance - you aren't addicted to the substance, you are addicted to the alteration of mood that the substance brings. ~ Susan Cheever

Cellular pathology is not an end if one cannot see any alteration in the cell. Chemistry brings the clarification of living processes nearer than does anatomy. Each anatomical change must have been preceded by a chemical one. ~ Rudolf Virchow

Youth is not a curse, but a fleeting blessing. Youth enables us to cavort freely unconcerned with the larger issues in life. Aging and the accompanying responsibilities that come with added maturity is what augments, vexes, and then excises us. Maturation represents the accumulation of supplanting changes happening in a person over time including physical, mental, and social growth and development. Growing old gracefully entails submission to biological alterations and witnessing unsettling changes in cultural and societal conventions. ~ Kilroy J. Oldster

One can describe the world of today to the people of today only if one describes it as capable of alteration. ~ Bertolt Brecht

Technology has already opened the door a bit wider for filmmakers, with smaller digital cameras making production less cumbersome. Social media is allowing self-distribution, and girl groups like Spark Summit are leading the way in calling for fewer Photoshop image alterations of girls in print media. ~ Sharon Lawrence

Complex PTSD consists of of six symptom clusters, which also have been described in terms of dissociation of personality. Of course, people who receive this diagnosis often also suffer from other problems as well, and as noted earlier, diagnostic categories may overlap significantly. The symptom clusters are as follows:
Alterations in Regulation of Affect ( Emotion ) and Impulses
Changes in Relationship with others
Somatic Symptoms
Changes in Meaning
Changes in the perception of Self
Changes in Attention and Consciousness ~ Suzette Boon

Isn't fixity the hallmark of the living dead? ~ Tom Robbins

Dissociation is the ultimate form of human response to chronic developmental stress, because patients with dissociative disorders report the highest frequency of childhood abuse and/or neglect among all psychiatric disorders. The cardinal feature of dissociation is a disruption in one or more mental functions. Dissociative amnesia, depersonalization, derealization, identity confusion, and identity alterations are core phenomena of dissociative psychopathology which constitute a single dimension characterized by a spectrum of severity.
Clinical Psychopharmacology and Neuroscience 2014 Dec; 12(3): 171-179
The Many Faces of Dissociation: Opportunities for Innovative Research in Psychiatry ~ Verdat Sar

For people steeped in biblical wonders and supernatural lore, alterations in the night sky, including the aurora borealis in northern latitudes, carried even greater portent. ~ A. Roger Ekirch

But if it so happens ... a work ... under pain of otherwise becoming shameful or false, requires fantasy ... [and that] certain limbs or elements of a figure are altered by borrowing from other species, for example transforming into a dolphin the hinder end of a griffon or a stag ... these alterations will be excellent and the substitution, however unreal it may seem, deserves to be declared a fine invention in the genre of the monstrous.
When a painter introduces into this kind of work of art chimerae and other imaginary beings in order to divert and entertain the senses and also to captivate the eyes of mortals who long to see unclassified and impossible things, he shows himself more respectful of reason than if he produced the usual figures of men or of animals. ~ Michelangelo Buonarroti

You get this drama, babe, you got until the end of Tack's meeting to burn it out, but mark this, Lanie. After that meeting, I don't give a fuck if you're strapped into a rocket to go to the goddamned moon, I'm findin' you, we're sortin' this shit out and we're movin' on," he warned. "I just made a mental note to find a plastic surgeon who does emergency face alterations so you won't know who to look for," I shot back. "Jesus, I'm pissed as all fuck and still she's cute," he groused like he wasn't talking to me but actually complaining to the Son of God. "Jesus works on Sunday, Hop. You want a direct line, time to haul your biker ass to church," I shared. "You want me to let you go so you can burn this out, you better stop bein' cute, lady. You keep bein' cute, I'll kiss you in the goddamn forecourt and I won't give a fuck who sees." I snapped my mouth shut. "That's what I thought," he ~ Kristen Ashley

SELFHOOD AND DISSOCIATION
The patient with DID or dissociative disorder not otherwise specified (DDNOS) has used their capacity to psychologically remove themselves from repetitive and inescapable traumas in order to survive that which could easily lead to suicide or psychosis, and in order to eke some growth in what is an unsafe, frequently contradictory and emotionally barren environment.

For a child dependent on a caregiver who also abuses her, the only way to maintain the attachment is to block information about the abuse from the mental mechanisms that control attachment and attachment behaviour.10 Thus, childhood abuse is more likely to be forgotten or otherwise made inaccessible if the abuse is perpetuated by a parent or other trusted caregiver.

In the dissociative individual, 'there is no uniting self which can remember to forget'. Rather than use repression to avoid traumatizing memories, he/she resorts to alterations in the self 'as a central and coherent organization of experience. . . DID involves not just an alteration in content but, crucially, a change in the very structure of consciousness and the self' (p. 187).29 There may be multiple representations of the self and of others.

Middleton, Warwick. "Owning the past, claiming the present: perspectives on the treatment of dissociative patients." Australasian Psychiatry 13.1 (2005): 40-49. ~ Warwick Middleton

Stressful situations cause alterations in behavior that reveal true character, Tibbs. If a person gradually begins acting like someone else altogether, you may very well find that they *are* someone else altogether" -Inspector Percival Pensive ~ Jessica Lawson

Addiction to alcohol is also a neurological phenomenon, the result of a complex set of molecular alterations that take place in the brain when it's excessively and repeatedly exposed to the drug. The science of addiction is complicated, but the basic idea is fairly straightforward: alcohol appears to wreak havoc on the brain's natural systems of craving and reward, compromising the functioning of the various neurotransmitters and proteins that create feelings of well-being. ~ Caroline Knapp

The more a sufferer concentrates on his symptoms, the deeper those symptoms are etched into his neural circuits. In the worst cases, the mind essentially trains itself to be sick. Many addictions, too, are reinforced by the strengthening of plastic pathways to the brain. Even very small doses of addictive drugs can dramatically alter the flow of neurotransmitters in a person's synapses, resulting in long-lasting alterations in brain circuitry and function. In some cases, the buildup of certain kinds of neurotransmitters, such as dopamine, a pleasure-producing cousin to adrenaline, seems to actually trigger the turning on or off particular genes, bringing even stronger cravings for the drug. The vital path turns deadly. ~ Nicholas Carr

Still, all it really took was one alteration in my life, a change which appeared insignificant and unlikely at the time, nonetheless it has affected my outlook completely, turning it around the compass of my life. ~ Andrew James Pritchard

I have never understood why they tried to start the revolution by taking over the universities. It should have been self-evident that the net result of success would be to close the universities but leave the nation unaffected
at least, for quite a long time. Nor do I find it easy to believe that the rebels, as intelligent as most of them were, seriously expected that they could keep the universities alive as corporate bodies, once they had control of them, if they made the fundamental alterations in organization and role that they proposed to. ~ Muriel Beadle

Biologists have long attempted by chemical means to induce in higher organisms predictable and specific changes which thereafter could be transmitted in series as hereditary characters. Among microorganisms the most striking example of inheritable and specific alterations in cell structure and function that can be experimentally induced and are reproducible under well defined and adequately controlled conditions is the transformation of specific types of Pneumococcus. ~ Oswald Avery

Emotion consists of a very well orchestrated set of alterations in the body that has, as a general purpose, making life more survivable by taking care of a danger, of taking care of an opportunity, either/or, or something in between. ~ Antonio Damasio

When you alter yourself, the alterations become the truth ... ~ Margaret Atwood

I met my grandfather just before he died, and it was the first time that I had seen Dad with a relative of his. It was interesting to see my own father as a son and the body language and alteration in attitude that comes with that, and it sort of changed our relationship for the better. ~ Christian Bale

There is no way to suppress change…not even in heaven; there is only a choice between a way of living which allows constant, if gradual alterations and a way of living that combines great control and cataclysmic upheavals. Those who panic and bind the trickster choose the latter path. It would be better to learn to play with him, better especially to develop skills (cultural, spiritual, artistic) that allow some commerce with accident, and some acceptance of the changes that contingency will always engender. ~ Lewis Hyde

Life is a self-correcting, negative regulatory system because it is always moving toward a specific target destination in the future. This target destination we call 'self preservation'.

Achieve this goal it must constantly reduce the probabilities that interfere with its movement toward that future target.

Hence, it conserves by self-regulating, like a thermostat set at a specific temperature, as it advances, all the while seeking to re-adapt in accordance with the changes it incurs.

Putting this principle to work in our daily life means learning to adapt to new information while always adhering to a basic plan that can, in general, be modified according to alterations in the data encountered.

Thoughts from; SPIRAL FORECASTING: Nature's Inside Track to Future Success ~ Nahu Lanham

When God calls a man, He does not repent of it. God does not, as many friends do, love one day, and hate another; or as princes, who make their subjects favourites, and afterwards throw theminto prison. This is the blessedness of a saint; his condition admits of no alteration. God's call is founded upon His decree, and His decree is immutable. Acts of grace cannot be reversed.God blots out His people's sins, but not their names. ~ Thomas Watson

Towards the preservation of your government, and the permanency of your present happy state, it is requisite, not only that you steadily discountenance irregular oppositions to its acknowledged authority, but also that you resist with care the spirit of innovation upon its principles, however specious the pretexts. One method of assault may be to effect, in the forms of the Constitution, alterations which will impair the energy of the system, and thus to undermine what cannot be directly overthrown. In all the changes to which you may be invited, remember that time and habit are at least as necessary to fix the true character of governments as of other human institutions; that experience is the surest standard by which to test the real tendency of the existing constitution of a country; that facility in changes, upon the credit of mere hypothesis and opinion, exposes to perpetual change, from the endless variety of hypothesis and opinion; and remember, especially, that for the efficient management of your common interests, in a country so extensive as ours, a government of as much vigor as is consistent with the perfect security of liberty is indispensable. ~ George Washington

It is changes that are chiefly responsible for diseases, especially the greatest changes, the violent alterations both in the seasons and in other things. ( ... regimen and temperature, and one period of life to another. ~ Hippocrates

Of course, the champions of totalitarianism protest that what they want to abolish is "only economic freedom" and that ali "other freedoms" will remain untouched. But freedom is indivisible. The distinction between an economic sphere of human life and activity and a noneconomic sphere is the worst of their fallacies. If an omnipotent authority has the power to assign to every individual the tasks he has to perform, nothing that can be called freedom and autonomy is left to him.
He has only the choice between strict obedience and death by starvation.1
Committees of experts may be called to advise the planning authority whether or not a young man should be given the opportunity to prepare himself for and to work in an intellectual or artistic field. But such an arrangement can merely rear disciples committed to the parrotIike repetition of the ideas of the preceding generation. It would bar innovators who disagree with the accepted ways of thought. No innovation would ever have been accomplished if its originator had been in need of an authorization by those from whose doctrines and methods he wanted to deviate. Hegel would not have ordained Schopenhauer or Feuerbach, nor would Professor Rau have ordained Marx or Carl Menger. If the supreme planning board is ultimately to determine which books are to be printed, who is to experiment in the laboratories and who is to paint or to sculpture, and which alterations in technological methods should be undertaken, there will ~ Ludwig Von Mises

That useful alterations will be suggested by experience, could not but be foreseen ... It moreover equally enables the general and state governments to originate the amendment of errors as they may be pointed out by the experience on one side or on the other. ~ James Madison

An occupying power has no right to make significant alterations in the character of the occupied society, to change the laws all around, without a strong security reason and so forth. ~ Juan Cole

Between 10 and 20 years to complete the course, from the first small alterations of character, tremors in the hands and face, emotional disturbance, including – most notably – sudden, uncontrollable alterations of mood, the helpless jerky dance-like movements, intellectual dilapidation, memory failure, agnosia, apraxia, dementia, total loss of muscular control rigidity sometimes, nightmarish hallucinations and a meaningless end. This is how the brilliant machinery of being is undone by the tiniest of faulty cogs, the insidious whisper of ruin, a single bad idea lodged in every cell, on every chromosome four. ~ Ian McEwan

You make alterations, affecting your pose, a new house, a new car, a new job, a new nose. ~ Ray Davies

That a language may retain its vitality and dignity, two things are necessary. In the first place, it must keep in close touch with life, and must respond to those constant alterations which look like corruptions but which are quite as often signs of growth. In the second place, it must submit to some kind of selective authority which creates a generally recognized but slowly changing norm of speech. Without the former condition a language will become rigid, conventional, and emotionless; without the second it will just as surely tend to become provincial and formless--even unintelligible, except locally and ephemerally. ~ Paul Elmer More

It was as if single nights had the duration of centuries, so within that time the most profound alterations in the whole of mankind, in the earth itself and the whole solar system could very well have taken place. ~ Daniel Paul Schreber

Of all the difficulties in a state, the temper of a true government most felicifies and perpetuates it; too sudden alterations distemper it. Had Nero tuned his kingdom as he did his harp, his harmony had been more honorable, and his reign more prosperous. ~ Francis Quarles

But the sages of Greece and Rome turned aside from the awful spectacle, and, pursuing the ordinary occupations of life and study, appeared unconscious of any alterations in the moral of physical government of the world. ~ Edward Gibbon

In my art history degree course, we did a module on palimpsests - medieval sheets of parchment so costly that, once the text was no longer needed, the sheets were simply scraped clean and reused, leaving the old writing faintly visible through the new. Later, Renaissance artists used the word pentimenti, repentances, to describe mistakes or alterations that were covered with new paint, only to be revealed years or even centuries later as the paint thinned with time, leaving both the original and the revision on view.

Sometimes I have a sense that this house - our relationship in it, with it, with each other - is like a palimpsest or pentimento, that however much we try to overpaint Emma Matthews, she keeps tiptoeing back: a faint image, an enigmatic smile, stealing its way into the corner of the frame. ~ J.P. Delaney

Can you not see the numerous designs made by God as signs, similitudes, or analogies of resurrection? He has placed them in every era, the alteration of day and night, even in the coming and going of clouds. ~ Said Nursi

How many serious family quarrels, marriages out of spite, and alterations of wills, might have been prevented by a gentle dose of blue pill!-What awful instances of chronic dyspepsia in the characters of Hamlet and Othello! Banish dyspepsia and spirituous liquors from society, and you have no crime, or at least so little that you would not consider it worth mentioning. ~ Charles Kingsley

The fact that Science walks forward on two feet, namely theory and experiment, is nowhere better illustrated than in the two fields for slight contributions to which you have done me the great honour of awarding the the Nobel Prize in Physics for the year 1923. Sometimes it is one foot that is put forward first, sometimes the other, but continuous progress is only made by the use of both - by theorizing and then testing, or by finding new relations in the process of experimenting and then bringing the theoretical foot up and pushing it on beyond, and so on in unending alterations. ~ Robert Andrews Millikan

In all provinces of life, it is unhappily the case, that whatever is to be accomplished by a number of co-operating men and circumstances cannot long continue perfect. Of an acting company as well as of a kingdom, of a circle of friends as well as of an army, you may commonly select the moment when it may be said that all was standing on the highest pinnacle of harmony, perfection, contentment, and activity. But alterations will ere long occur; the individuals that compose the body often change; new members are added; the persons are no longer suited to the circumstances, or the circumstances to the persons; what was formerly united quickly falls asunder. ~ Johann Wolfgang Von Goethe

Time is a dressmaker specializing in alterations ~ Faith Baldwin

The Avatar does not as a rule interfere with the working out of human destinies. He will do so only in times of grave necessity when He deems itabsolutely necessary from His all encompassing point of view. For a single alteration in the planned and imprinted pattern in which each line and dot is interdependent, means a shaking up and a re-linking of an unending chain of possibilities and events. ~ Meher Baba

Contentment is never the outcome of fulfillment, of achievement, or of the possession of things; it is not born of action or inaction. It comes with the fullness of what is, not in the alteration of it. ~ Jiddu Krishnamurti

I hold it perniciously false to teach that all cultural forms are equally probable and that by mere force of will an inspired individual can at any moment alter the trajectory of an entire cultural system in a direction convenient to any philosophy. Convergent and parallel trajectories far outnumber divergent trajectories in cultural evolution. Most people are conformists. History repeats itself in countless acts of individual obedience to cultural rule and pattern, and individual wills seldom prevail in matters requiring radical alterations of deeply conditioned beliefs and practices.
At the same time, nothing I have written in this book supports the view that the individual is helpless before the implacable march of history or that resignation and despair are appropriate responses to the concentration of industrial managerial power. The determinism that has governed cultural evolution has never been the equivalent of the determinism that governs a closed physical system. Rather, it resembles the causal sequences that account for the evolution of plant and animal species. ~ Marvin Harris

Holmes smiled, and clapped Lestrade upon the shoulder. "Instead of being ruined, my good sir, you will find that your reputation has been enormously enhanced. Just make a few alterations in that report which you were writing, and they will understand how hard it is to throw dust in the eyes of Inspector Lestrade." "And you don't want your name to appear?" "Not at all. The work is its own reward. Perhaps I shall get the credit also at some distant day, when I permit my zealous historian to lay out his foolscap once more
eh, Watson? ~ Arthur Conan Doyle

The arguments in favour of offering something to a previously disprivileged group are all very well and they do have weight. But much more important is the effect of this on the institution of marriage. My view is that here we need some serious anthropology. You have to recognise that rites of passage are not personal possessions, they are possessions of the whole community, they are the ways in which the community defines itself and defines its obligation towards the next generation. So you don't make these radical, metaphysical alterations to an institution such as marriage without there being long-term consequences. And nobody seemed to want to talk about the long-term consequences. ~ Roger Scruton

It would probably be wiser to nail up over the door of the new quantum theory a notice, 'Structural alterations in progress - No admittance except on business', and particularly to warn the doorkeeper to keep out prying philosophers. ~ Arthur Stanley Eddington

Fashion is more about taste than money - you have to understand your body and tailor clothes to your needs; it's all about the fit. I do the alterations myself - I'm quite a seamstress - it's the influence of my Hungarian mother. ~ Carmen Dell'Orefice

It is hard to resist the impression that the present structure of the universe, apparently so sensitive to minor alterations in numbers, has been rather carefully thought out ... The seemingly miraculous concurrence of these numerical values must remain the most compelling evidence for cosmic design. ~ Paul Davies

You should move toward whatever changes, whatever surgeries, whatever renovations or alterations or restorations will create you in the glory you deserve, oh yes you should. And you should do it with your usual style, and you should do it without shame, and when you're healed up and ready we can go shopping for something fabulous to showcase the many wonders of you. But ~ S. Bear Bergman

So, Einstein's theory of gravity is a theory of causal structure. It tells us that the essence of spacetime is causal structure and that the motion of matter is a consequence of alterations in the network of causal relations. What is left out from the notion of causal structure is any measure of quantity or scale. ~ Lee Smolin

And graphic design elements and alterations are property of Bookbyte Digital and may be used as long as credit ~ Lewis Carroll

There are people who might be with you for much of your waking hours for many years, yet when they are gone you find they've left the smallest of marks on you. There are others who will always mark you deeply no matter how little the time they spend with you. Those people leave you with scars and blemishes, with love kisses, with mind-bending alterations of whatever it is inside that makes you who you are. ~ Cari Silverwood

During shooting, you have the idea, like, of this certain dress on this actress, but it's not to fit, so you have to make all of these alterations and modifications. So in a way, I build the characters with the cast, and it's sort of custom-made, the whole process, and then you have to make all of these adjustments. ~ Wong Kar-Wai

It was the fashion of the times to attribute every remarkable event to the particular will of the Deity; the alterations of nature were connected, by an invisible chain, with the moral and metaphysical opinions of the human mind; and the most sagacious divines could distinguish, according to the colour of their respective prejudices, that the establishment of heresy tended to produce an earthquake, or that a deluge was the inevitable consequence of the progress of sin and error. ~ Edward Gibbon

All is more or less proper to serve as a common measure, in proportion as it is more or less in general use, of a more similar quality, and more easy to be divided into aliquot parts. All is more or less applicable for the purpose of a general pledge of exchange, in proportion as it is less susceptible of decay or alteration in quantity or quality. ~ Anne-Robert-Jacques Turgot, Baron De Laune

No matter what these terrorists do, I refuse to be terrorized. All this requires is just a few alterations in our day to day lives. For example, my first instinct when I receive an envelope full of white powder ... is to snort it! I just won't do that this time! ~ Margaret Cho

The problem with radio frequency (RF) exposure is not the small amount of brain tumors, is it the large amount of subtle alterations in the brain that lead to attention, confusion, insomnia and fatigue problems. ~ Steven Magee

In these pages, it is my intention to make many people - not only Muslims but also Western apologists for Islam - uncomfortable. I am not going to do this by drawing cartoons. Rather, I intend to challenge centuries of religious orthodoxy with ideas and arguments that I am certain will be denounced as heretical. My argument is for nothing less than a Muslim Reformation. Without fundamental alterations to some of Islam's core concepts, I believe, we shall not solve the burning and increasingly global problem of political violence carried out in the name of religion. I intend to speak freely, in the hope that others will debate equally freely with me on what needs to change in Islamic doctrine, rather than seeking to stifle discussion. ~ Ayaan Hirsi Ali

Environmental influences also affect dopamine. From animal studies, we know that social stimulation is necessary for the growth of the nerve endings that release dopamine and for the growth of receptors that dopamine needs to bind to in order to do its work. In four-month-old monkeys, major alterations of dopamine and other neurotransmitter systems were found after only six days of separation from their mothers.

"In these experiments," writes Steven Dubovsky, Professor of Psychiatry and Medicine at the University of Colorado, "loss of an important attachment appears to lead to less of an important neurotransmitter in the brain. Once these circuits stop functioning normally, it becomes more and more difficult to activate the mind."

A neuroscientific study published in 1998 showed that adult rats whose mothers had given them more licking, grooming and other physical-emotional contact during infancy had more efficient brain circuitry for reducing anxiety, as well as more receptors on nerve cells for the brain's own natural tranquilizing chemicals. In other words, early interactions with the mother shaped the adult rat's neurophysiological capacity to respond to stress.

In another study, newborn animals reared in isolation had reduced dopamine activity in their prefrontal cortex - but not in other areas of the brain. That is, emotional stress particularly affects the chemistry of the prefrontal cortex, the center for selective attention, motiv ~ Gabor Mate

In network models of the interactome, these truncating mutations can be thought of as the removal of one node along with all its edges - a node removal. Nonconservative missense mutations of amino acids in the protein core that lead to major folding problems, protein aggregation, and premature protein degradation can also be modeled as node removals. At the other end of the mutational spectrum are small in-frame indels or missense mutations. These can preserve protein folding, but may modify the active site of an enzyme or affect the binding to another protein or macromolecule. In network models, these mutations, which specifically perturb a single molecular interaction, have been labeled as edge-specific or "edgetic". While investigation of the precise interaction defects associated with point mutations is of course not new, the term edgetic promotes a subtle yet meaningful archetype shift from conventional gene-centered models, which emphasize consideration of which specific edges are affected by a mutation, complement and extend classic gene-centric models, which ascertain only whether a gene product is present or not present and neglect less overt alterations of a given gene or gene product. ~ Joseph Loscalzo

Over human timescales, however, our disruption of geography will haunt us. Soil lost to erosion, coastal areas claimed by the sea, and mountaintops sacrificed on the altar of capitalism won't be restored in our lifetime. And these alterations will set in motion a cascade of side effects--hydrologic, biological, social, economic, and political--that will define the human agenda for centuries. ~ Marcia Bjornerud

Now, there is always a tremendous fear of science and progressing forward into areas of the unknown and it is a valid fear. Some of the genetic alterations of food are a little edgy. ~ Nick Nolte

It is good that you exist and that we exist together." It's only when lovers recognize this depth dimension in each other that their love becomes hardy enough to outlast changes in their feelings or alterations in their qualities and attributes. What genuine lovers care about most is not simply whether the beloved can give him- or herself freely to them in return. True lovers who have attained the maturity of love are able to recognize that the beloved him- or herself is a gift, ~ Carl A. Anderson

one may need to undergo several regimens of training and sample several different professions before determining where one's strongest talents lie. This is the driving force behind many life-path alterations. There are few sets of skills that match only one specific job. More often they are adaptable to many different professions. Sometimes, one can plan such a change. Other times, the change appears without warning. In both instances, one must be alert and carefully consider all options. Not every change is a step forward. - ~ Timothy Zahn

Everything that makes diversity of kinds, of species, differences, properties ... everything that consists in generation, decay, alteration and change is not an entity, but a condition and circumstance of entity and being, which is one, infinite, immobile, subject, matter, life , death , truth , lies , good and evil . ~ Giordano Bruno

"Pieces" almost always appear 'as parts' in whole processes ... To sever a "'part" from the organized whole in which it occurs-whether it itself be a subsidiary whole or an "element"-is a very real process usually involving alterations in that "part". Modifications of a part frequently involve changes elsewhere in the whole itself. Nor is the nature of these alterations arbitrary, for they too are determined by whole-conditions. ~ Max Wertheimer

Next to this central belief which,while I was reading, would be constantly reaching out from my inner self to the outer world, towards the discovery of truth, came the emotions aroused in me by the action in which I was taking part, for these afternoons were crammed with more dramatic events than occur, often, in a whole lifetime. These were the events taking Place in the book I was reading. It is true that the people concerned in them were not what Francoise would have called "real people." .... it matters not that the actions, the feelings of this new order of creatures appear to us in the guise of truth, since we have made them our own, since it is in ourselves that they are happening, that they are holding in thrall, as we feverishly turn over the pages of the book, our quickened breath and staring eyes. And once the novelist has brought us to this state, in which, as in all purely mental states, every emotion is multiplied ten-fold, into which his book comes to disturb us as might a dream, but a dream more lucid and more abiding than those which come to us in sleep, why then, for the space of an hour he sets free within us all the joys and sorrows in the world, a few of which only we should have to spend years of our actual life in getting to know, and the most intense of which would never be revealed to us of their development prevents us from perceiving them. It is the same in life; the heart changes, and it is our worst sorrow; but we know it only through reading, thr ~ Marcel Proust

At the meeting he was struck for the first time by the endless variety of men's minds, which prevents a truth from ever presenting itself identically to two persons. Even those members who seemed to be on his side understood him in their own way with limitations and alterations he could not agree to, as what he always wanted most was to convey his thought to others just as he himself understood it. ~ Leo Tolstoy

In gravitational fields there are no such thing as rigid bodies with Euclidean properties; thus the fictitious rigid body of reference is of no avail in the general theory of relativity. ...
For this reason non-rigid reference-bodies are used, which are, as a whole, not only moving in any way whatsoever, but which also suffer alterations in form ad lib. during their motion...
This non-rigid reference-body, ... might appropriately be termed a "reference mollusc,"... ~ Albert Einstein

In a word there seems to be the light of the outer world, of those who know the sun and moon emerge at such an hour and such another plunge again below the surface, and who rely on this, and who know that clouds are always to be expected but sooner or later always pass away, and mine. But mine too has its alterations, I will not deny it, its dusks and dawns, but that is what I say, for I too must have lived, once, out there, and there is no recovering from that. ~ Samuel Beckett

Studies by Andrew Newberg and others have shown that long-term practice of meditation produces significant alterations in cerebral blood flow in parts of the brain related to attention, emotion, and some autonomic functions. ~ Oliver Sacks

All of us have read of what occured during that interval. The tale is in every Englishman's mouth; and you and I, who were children when the great battle was won and lost, are never tired of hearing and recounting the history of that famous action. Its rememberance rankles still in the bosoms of millions of the countrymen of those brave men who lost the day. They pant for an opportunity of revenging that humiliation; and if a contest, ending in a victory on their part, should ensue, elating them in their turn, and leaving its cursed legacy of hatred and rage behind to us, there is no end to the so-called glory and shame, and to the alterations of successful and unsuccessful murder, in which two high-spirited nations might engage. Centuries hence, we Frenchmen and Englishmen might be boasting and killing each other still, carrying out bravely the Devil's code of honor. ~ William Makepeace Thackeray

Reagan took an approach to the Cold War dramatically different from any other US President. To wit, he thought we should win. This was a fresh concept. At the time, it was widely ridiculed as a dangerous alteration of US policy. Only after it worked was Reagan's dangerous foreign policy recast as merely a continuation of the policies of his predecessors. ~ Ann Coulter

But this first installation was by no means the last. Every year the Queen had some new fancy for beautifying her miniature kingdom with more highly artificial and more "natural" additions and alterations. ~ Stefan Zweig

Your ideas about right and wrong are just that-ideas. They are the thoughts which form the shape and create the substance of Who You Are. There would be only one reason to change any of these; only one purpose in making an alteration: if you are not happy with Who You Are. ~ Neale Donald Walsch

Circadian rhythms are implicated in some of the symptoms of depression, such as early awakening and diurnal variation in mood. The possible importance of the circadian system in its pathogenesis is suggested by the capacity of experimental alterations in the timing of sleep and wakefulness to alter clinical state." Biological rhythms range in frequency from milliseconds to months or years. Most rhythmic disturbances identified in the symptoms of manic-depressive illness occur over the course of a day-that is, they are circadian rhythms-and are most apparent in the daily rest-activity cycle. The episodic recurrences of the illness, on the other hand, are usually infradian, oscillating over periods of months or years. Episodic mania and depression may also reflect disturbances in ultradian rhythms, those that oscillate more than once a day, which are common at the cellular level and in hormone secretion, as well as in such autonomic functions as circulation, blood pressure, respiration, heart rate, and in the cycles of sleep. ~ Kay Redfield Jamison

Hello again,' she said, shivering in the night air.'Good eve, fair lady, your forgiveness we implore, to come so brashly tapping, tapping at your chamber door.'Oh, well, this isn't exactly my chamber door. More like a window, actually.'The Raven bobbed his head. 'I made some alterations for the sake of the rhyme.'I see. Well – good evening, fair Raven, my forgiveness I bestow, for this uncanny meeting outside of my window.'A boisterous laugh startled Catherine, sending her heart into her throat. ~ Marissa Meyer

The images are compositions of photos superimposed over painted backgrounds, then finished off with digital alterations. ~ Loretta Lux

Changes ... can only be effected by alterations in the original. The only thing not prerecorded in a prerecorded universe are the prerecordings themselves. The copies can only repeat themselves word for word. A virus is a copy. You can pretty it up, cut it up, scramble it - it will reassemble in the same form. ~ William S. Burroughs

Use-induced cortical reorganization, says Taub, "involves alterations different from mere learning and memory. Rather than producing just increased synaptic strength at certain junctions, which is believed to underlie learning, some unknown mechanism is instead producing wholesale topographic reorganization." And more: we are seeing evidence of the brain's ability to remake itself throughout adult life, not only in response to outside stimuli but even in response to directed mental effort. We are seeing, in short, the brain's potential to correct its own flaws and enhance its own capacities. ~ Jeffrey M. Schwartz

Pathological dissociation is characterized by profound, functional amnesias and significant alterations in identity; normal dissociation is expressed primarily in the form of intense absorption with internal stimuli (e.g., daydreams) or external stimuli (e.g., a fascinating book or television program). ~ Frank W. Putnam