Robert M. Sapolsky Quotes

On an incredibly simplistic level, you can think of depression as occurring when your cortex thinks an abstract thought and manages to convince the rest of the brain that this is as real as a physical stressor.

If I had to define a major depression in a single sentence, I would describe it as a genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.

By using two elephants to do the job, damage will occur just because of how large, lumbering, and unsubtle elephants are. They squash the flowers in the process of entering the playground, they strew leftovers and garbage all over the place from the frequent snacks they must eat while balancing the seesaw, they wear out the seesaw faster, and so on. This is equivalent to a pattern of stress-related disease that will run through many of the subsequent chapters: it is hard to fix one major problem in the body without knocking something else out of balance (the very essence of allostasis spreading across systems throughout the body). Thus, you may be able to solve one bit of imbalance brought on during stress by using your elephants (your massive levels of various stress hormones), but such great quantities of those hormones can make a mess of something else in the process. And a long history of doing this produces wear and tear throughout the body, termed allostatic load.

Everything in physiology follows the rule that too much can be as bad as too little. There are optimal points of allostatic balance. For example, while a moderate amount of exercise generally increases bone mass, thirty-year-old athletes who run 40 to 50 miles a week can wind up with decalcified bones, decreased bone mass, increased risk of stress fractures and scoliosis (sideways curvature of the spine) - their skeletons look like those of seventy-year-olds. To put exercise in perspective, imagine this: sit with a group of hunter-gatherers from the African grasslands and explain to them that in our world we have so much food and so much free time that some of us run 26 miles in a day, simply for the sheer pleasure of it. They are likely to say, "Are you crazy? That's stressful." Throughout hominid history, if you're running 26 miles in a day, you're either very intent on eating someone or someone's very intent on eating you.

An open mind is a prerequisite to an open heart.

The subject of one experiment is a rat that receives mild electric shocks (roughly equivalent to the static shock you might get from scuffing your foot on a carpet). Over a series of these, the rat develops a prolonged stress-response: its heart rate and glucocorticoid secretion rate go up, for example. For convenience, we can express the long-term consequences by how likely the rat is to get an ulcer, and in this situation, the probability soars. In the next room, a different rat gets the same series of shocks - identical pattern and intensity; its allostatic balance is challenged to exactly the same extent. But this time, whenever the rat gets a shock, it can run over to a bar of wood and gnaw on it. The rat in this situation is far less likely to get an ulcer. You have given it an outlet for frustration. Other types of outlets work as well - let the stressed rat eat something, drink water, or sprint on a running wheel, and it is less likely to develop an ulcer.

Finish this lecture, go outside, and unexpectedly get gored by an elephant, and you are going to secrete glucocorticoids. There's no way out of it. You cannot psychologically reframe your experience and decide you did not like the shirt, here's an excuse to throw it out - that sort of thing.

Depression is not generalized pessimism, but pessimism specific to the effects of one's own skilled action.

Prior to the monotheistic Yahweh, the gods made sense, in that they had familiar, if supra-human appetites - they didn't just want a lamb shank, they wanted the best lamb shank, wanted to seduce all the wood nymphs, and so on. But the early Jews invented a god with none of those desires, who was so utterly unfathomable, unknowable, as to be pants-wettingly terrifying. So even if His actions are mysterious, when He intervenes you at least get the stress-reducing advantages of attribution - it may not be clear what the deity is up to, but you at least know who is responsible for the locust swarm or the winning lottery ticket. There is Purpose lurking, as an antidote to the existential void.

Fossey, Fossey, you cranky difficult strong-arming self-destructive misanthrope, mediocre scientist, deceiver of earnest college students, probable cause of more deaths of the gorillas than if you had never set foot in Rwanda, Fossey, you pain-in-the-ass saint, I do not believe in prayers or souls, but I will pray for your soul, I will remember you for all of my days, in gratitude for that moment by the graves when all I felt was the pure, cleansing sadness of returning home and finding nothing but ghosts.

If you live in a baboon troop in the Serengeti, you only have to work three hours a day for your calories, and predators don't mess with you much. What that means is you've got nine hours of free time every day to devote to generating psychological stress toward other animals in your troop. So the baboon is a wonderful model for living well enough and long enough to pay the price for all the social-stressor nonsense that they create for each other. They're just like us: They're not getting done in by predators and famines, they're getting done in by each other.

During one wave, I suddenly found myself cramped over in front of my tent, stark naked, painful, liquid acidic craps, and, the humiliation of it all, surrounded by six elephants, silent, quizzical, polite, murmuring, almost solicitous, their trunks waving in the air investigating my actions and moans. They watched my agonized shitting as if it were an engrossing, silent Shakespearean tragedy performed in the round.

We're getting along so well; I trust you so much for this one second that I'm going to let you yank on me.

Medicine is a social science, and politics nothing but medicine on a large scale,

A behavior has occurred that is good, bad, or ambiguous. How have cultural factors stretching back to the origins of humans contributed to that behavior? And rustling cattle on a moonless night; or setting aside tending your cassava garden to raid your Amazonian neighbours; or building fortifications; or butchering every man, woman, and child in a village is irrelevant to that question. That's because all these study subjects are pastoralists, agriculturalists, or horticulturalists, lifestyles that emerged only in the last ten thousand to fourteen thousand years, after the domestication of plants and animals. In the context of hominin history stretching back hundreds of thousands of years, being a camel herder or farmer is nearly as newfangled as being a lobbyist advocating for legal rights for robots. For most of history, humans have been hunter-gatherers, a whole different kettle of fish.

Most people who do a lot of exercise, particularly in the form of competitive athletics, have unneurotic, extraverted, optimistic personalities to begin with. (Marathon runners are exceptions to this.)

Part of the reason for the evolutionary success of primates, human or otherwise, is that we are a pretty smart collection of animals. What's more, our thumbs work in particularly fancy and advantageous ways, and we're more flexible about food than most. But our primate essence is more than just abstract reasoning, dexterous thumbs, and omnivorous diets. Another key to our success must have something to do with this voluntary transfer process, this primate legacy of feeling an itch around adolescence.

In other words, dopamine is not about the happiness of reward. It's about the happiness of pursuit of reward that has a decent chance of occurring.

Essentially, we humans live well enough and long enough, and are smart enough, to generate all sorts of stressful events purely in our heads.

Willpower is more than just a metaphor; self-control is a finite resource.

If you have to boil this book down to a single phrase, it would be "it's complicated.

Brain-imaging studies of drug users at that stage show that viewing a film of actors pretending to use drugs activates dopamine pathways in the brain more than does watching porn films. This

I might continue to believe that there is no god even if it were proved that there is. A religious friend of mine once remarked that the concept of god is useful, because you can berate god during the bad times. But it is clear to me that I don't need to believe there is a god in order to berate him.

Genes are rarely about inevitability, especially when it comes to humans, the brain, or behavior. They're about vulnerability, propensities, tendencies.

Being healthy consists of having the same disease as everyone else.

But if you get chronically, psychosocially stressed, you're going to compromise your health. So, essentially, we've evolved to be smart enough to make ourselves sick.

If we were designed by engineers, as we consumed more, we'd desire less. But our frequent human tragedy is that the more we consume, the hungrier we get. More and faster and stronger. What was an unexpected pleasure yesterday is what we feel entitled to today, and what won't be enough tomorrow.

Obviously, oxytocin and vasopressin are the grooviest hormones in the universe. Pour them into the water supply, and people will be more charitable, trusting, and empathic. We'd be better parents and would make love, not war (mostly platonic love, though, since people in relationships would give wide berths to everyone else). Best of all, we'd buy all sorts of useless crap, trusting the promotional banners in stores once oxytocin starts spraying out of the ventilation system.

How much you groom somebody else is more important than who grooms you.

The brain is heavily influenced by genes. But from birth through young adulthood, the part of the human brain that most defines us (frontal cortex) is less a product of the genes with which you started life than of what life has thrown at you. Because it is the least constrained by genes and most sculpted by experience. This must be so, to be the supremely complex social species that we are. Ironically, it seems that the genetic program of human brain development has evolved to, as much as possible, free the frontal cortext from genes.

First, can fetal or childhood exposure to synthetic glucocorticoids have lifelong, adverse effects? Glucocorticoids (such as hydrocortisone) are prescribed in vast amounts, because of their immunosuppressive or anti-inflammatory effects. During pregnancy, they are administered to women with certain endocrine disorders or who are at risk for delivering preterm. Heavy administration of them during pregnancy has been reported to result in children with smaller head circumferences, emotional and behavioral problems in childhood, and slowing of some developmental landmarks. Are these effects lifelong? No one knows.

I am not worried if scientists go and explain everything. This is for a very simple reason: an impala sprinting across the Savannah can be reduced to biomechanics, and Bach can be reduced to counterpoint, yet that does not decrease one iota our ability to shiver as we experience impalas leaping or Bach thundering. We can only gain and grow with each discovery that there is structure underlying the most accessible levels of things that fill us with awe.

But there is an even stronger reason why I am not afraid that scientists will inadvertently go and explain everything--it will never happen. While in certain realms, it may prove to be the case that science can explain anything, it will never explain everything. As should be obvious after all these pages, as part of the scientific process, for every question answered, a dozen newer ones are generated. And they are usually far more puzzling, more challenging than than the prior problems. This was stated wonderfully in a quote by a geneticist named Haldane earlier in the century: "Life is not only stranger than we imagine, it is stranger than we can imagine." We will never have our flames extinguished by knowledge. The purpose of science is not to cure us of our sense of mystery and wonder, but to constantly reinvent and reinvigorate it.

When doing science (or perhaps when doing anything at all in a society as judgmental as our own), be very careful and very certain before pronouncing something to be a norm - because at that instant, you have made it supremely difficult to ever again look objectively at an exception to that supposed norm.

Things that seem morally obvious and intuitive now weren't necessarily so in the past; many started with nonconforming reasoning.

Get it wrong, and we call it a cult. Get it right, in the right time and the right place, and maybe, for the next few millennia, people won't have to go to work on your birthday.

Males who do extreme amounts of exercise, such as professional soccer players and runners who cover more than 40 or 50 miles a week, have less LHRH, LH, and testosterone in their circulation, smaller testes, less functional sperm. They also have higher levels of glucocorticoids in their bloodstreams, even in the absence of stress. (A similar decline in reproductive function is found in men who are addicted to opiate drugs.)