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Kirk Erickson and colleagues in Art Kramer's lab hypothesized that the well-documented shrinkage of the brain with age would be reduced by exercise. They used structural scans to measure hippocampal volume in 165 healthy older people who varied in their level of physical fitness. The hippocampus is a structure deep in the temporal lobes long known to be critical for forming new memories. They found that people who showed higher aerobic fitness had larger hippocampi bilaterally. Moreover, the fitter group also showed better spatial memory performance than the less fit group.
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