Telomerase Quotes

They also knew that there was a string of DNA at the end of each chromosome called a telomere, which shortened a tiny bit each time a cell divided, like time ticking off a clock. As normal cells go through life, their telomeres shorten with each division until they're almost gone. Then they stop dividing and begin to die. This process correlates with the age of a person: the older we are, the shorter our telomeres, and the fewer times our cells have left to divide before they die. By the early nineties, a scientist at Yale had used HeLa to discover that human cancer cells contain an enzyme called telomerase that rebuilds their telomeres. The presence of telomerase meant cells could keep regenerating their telomeres indefinitely. This explained the mechanics of HeLa's immortality: telomerase constantly rewound the ticking clock at the end of Henrietta's chromosomes so they never grew old and never died. ~ Rebecca Skloot

Cancer cells have had so many other things go wrong with them, genetic, non-genetic changes, that those cells, one of the things they then get selected for is that they have lots of telomerase because now the telomeres in those cells get maintained. ~ Elizabeth Blackburn

When you bring telomerase RNA levels down by using a mechanism that targets the RNA for destruction, the cells which were running on very high telomerase levels are now running on a lean diet of telomerase. ~ Elizabeth Blackburn

Another clue to the cause of aging might be telomerase, which helps to regulate our biological clock. Every time a cell divides, the tips of the chromosomes, called telomeres, get a bit shorter. Eventually, after approximately fifty to sixty divisions, the telomeres become so short that they disappear and the chromosome begins to fall apart, so the cell enters a state of senescence and no longer functions correctly. Thus there is a limit to how many times a cell can divide, called the Hayflick limit. ~ Michio Kaku