Siddhartha Quotes

Being born a princess is all right, but behaving like one can be dangerous. ~ Siddhartha Choudhary

How deaf and stupid have I been!" he thought, walking swiftly along.
"When someone reads a text, wants to discover its meaning, he will not
scorn the symbols and letters and call them deceptions, coincidence, and
worthless hull, but he will read them, he will study and love them, letter
by letter. But I, who wanted to read the book of the world and the book
of my own being, I have, for the sake of a meaning I had anticipated be-fore I read, scorned the symbols and letters, I called the visible world a
deception, called my eyes and my tongue coincidental and worthless
forms without substance. No, this is over, I have awakened, I have in-deed awakened and have not been born before this very day. ~ Hermann Hesse

In August 1867, a thirteen-year-old142 boy who had severely cut his arm while operating a machine at a fair in Glasgow was admitted to Lister's infirmary. The boy's wound was open and smeared with grime - a setup for gangrene. But rather than amputating the arm, Lister tried a salve of carbolic acid, hoping to keep the arm alive and uninfected. The wound teetered on the edge of a terrifying infection, threatening to become an abscess. But Lister persisted, intensifying his application of carbolic acid paste. For a few weeks, the whole effort seemed hopeless. But then, like a fire running to the end of a rope, the wound began to dry up. A month later, when the poultices were removed, the skin had completely healed underneath. ~ Siddhartha Mukherjee

It is said that if you know your enemies and know yourself, you will not be imperiled in a hundred battles; if you do not know your enemies but do know yourself, you will win one and lose one; if you do not know your enemies nor yourself, you will be imperiled in every single battle. - Sun Tzu ~ Siddhartha Mukherjee

I think you would have to be a nihilist to say that we are not making progress on cancer, just like you'd have to be hubristically optimistic to say that we have conquered cancer. ~ Siddhartha Mukherjee

The secret to battling cancer, then, is to find means to prevent these mutations from occurring in susceptible cells, or to find means to eliminate the mutated cells without compromising normal growth. The conciseness of that statement belies the enormity of the task. Malignant growth and normal growth are so genetically intertwined that unbraiding the two might be one of the most significant scientific challenges faced by our species. Cancer is built into our genomes: the genes that unmoor normal cell division are not foreign to our bodies, but rather mutated, distorted versions of the very genes that perform vital cellular functions. And cancer is imprinted in our society: as we extend our life span as a species, we inevitably unleash malignant growth (mutations in cancer genes accumulate with aging; cancer is thus intrinsically related to age). If we seek immortality, then so, too, in a rather perverse sense, does the cancer cell. ~ Siddhartha Mukherjee

Indeed, cancer's emergence in the world is the product of a double negative: it becomes common only when all other killers themselves have been killed. ~ Siddhartha Mukherjee

Writing anything as an expert is really poisonous to the writing process, because you lose the quality of discovery. ~ Siddhartha Mukherjee

And when Siddhartha was listening attentively to this river, this song of a thousand voices, when he neither listened to the suffering nor the laughter, when he did not tie his soul to any particular voice and submerged his self into it, but when he heard them all, perceived the whole, the oneness, then the great song of the thousand voices consisted of a single word, which was Om: the perfection. ~ Hermann Hesse

In 2010, about six hundred thousand Americans, and more than 7 million humans around the world, will die of cancer. In the United States, one in three women and one in two men will develop cancer during their lifetime. A quarter of all American deaths, and about 15 percent of all deaths worldwide, will be attributed to cancer. In some nations, cancer will surpass heart disease to become the most common cause of death. ~ Siddhartha Mukherjee

It turns out that the very genes that turn on in cancer cells perform vital functions in normal cells. In other words, the very genes that allow our embryos to grow or our brains to grow, our bodies to grow, if you mutate them, if you distort them, then you unleash cancer. ~ Siddhartha Mukherjee

Is medicine a science? ~ Siddhartha Mukherjee

Our ability to read out this sequence of our own genome has the makings of a philosophical paradox. Can an intelligent being comprehend the instructions to make itself? - John Sulston Scholars ~ Siddhartha Mukherjee

There's a phrase in Shakespeare: he refers to it as the 'hidden imposthume', and this idea of a hidden swelling is seminal to cancer. But even in more contemporary writing it's called 'the big C'. ~ Siddhartha Mukherjee

Three profoundly destabilizing scientific ideas ricochet through the twentieth century, trisecting it into three unequal parts: the atom, the byte, the gene. ~ Siddhartha Mukherjee

In the shade of the house, in the sunshine of the riverbank near the boats, in the shade of the Sal-wood forest, in the shade of the fig tree is where Siddhartha grew up, the handsome son of the Brahman, the young falcon, together with his friend Govinda, son of a Brahman. The sun tanned his light shoulders by the banks of the river when bathing, performing the sacred ablutions, the sacred offerings. In the mango grove, shade poured into his black eyes, when playing as a boy, when his mother sang, when the sacred offerings were made, when his father, the scholar, taught him, when the wise men talked. For a long time, Siddhartha had been partaking in the discussions of the wise men, practising debate with Govinda, practising with Govinda the art of reflection, the service of meditation. He already knew how to speak the Om silently, the word of words, to speak it silently into himself while inhaling, to speak it silently out of himself while exhaling, with all the concentration of his soul, the forehead surrounded by the glow of the clear-thinking spirit. He already knew to feel Atman in the depths of his being, indestructible, one with the universe. ~ Hermann Hesse

Children with cancer, as one surgeon noted, were typically "tucked in the farthest recesses of the hospital wards." They were on their deathbeds anyway, the pediatricians argued; wouldn't it be kinder and gentler, some insisted, to just "let them die in peace"? ~ Siddhartha Mukherjee

Siddhartha does nothing, he waits, he thinks, he fasts, but he passes through the things of the world like a rock through water, without doing anything, without stirring; he is drawn, he lets himself fall. His goal attracts him, because he doesn't let anything enter his soul which might oppose the goal. ~ Hermann Hesse

Siddhartha listened. He was now completely and utterly immersed in his listening, utterly empty, utterly receptive; he felt he had now succeeded in learning how to listen. He had heard all these things often now, these many voices in the river; today it sounded new. Already he could no longer distinguish the many voices, could not distinguish the gay from the weeping, the childish from the virile; they all belonged together, the yearning laments and the wise man's laughter, the cry of anger and the moans of the dying; they were all one, all of them interlinked and interwoven, bound together in a thousand ways. And all of this together - all the voices, all the goals, all the longing, all the suffering, all the pleasure, everything good and everything bad - all of it together was the world. All of it together was the river of occurrences, the music of life. And when Siddhartha listened attentively to this river, to this thousand-voiced song, when he listened neither for the sorrow nor for the laughter, when he did not attach his soul to any one voice and enter into it with his ego but rather heard all of them, heard the whole, the oneness - then the great song of the thousand voices consisted only of a single word: Om, perfection. ~ Hermann Hesse

The reason why I do not know anything about myself, the reason why Siddhartha has remained alien and unknown to myself is due to one thing, to one single thing
I was afraid of myself, I was fleeing from myself. I was seeking Atman, I was seeking Brahman, I was determined to dismember myself and tear away its layers of husk in order to find in its unknown innermost recess the kernel at the heart of those layers, the Atman, life, the divine principle, the ultimate. But in so doing, I was losing myself. ~ Hermann Hesse

He whispered in the king's ear, "If you ask me, I think you should find a wife for Siddhartha. Once he has a family to occupy him, he will abandon this desire to become a monk." King Suddhodana nodded. ~ Thich Nhat Hanh

Nécessité absolue trouver origine de cet emmerdement [It is absolutely necessary to find the origin of this pain in the ass]. - Jacques Monod ~ Siddhartha Mukherjee

Finally, the tern 'asceticism' is also susceptible to being misunderstood by those who view Buddhism from the outside. Evola reminds his readers that the original meaning of the term asceticism is "practical exercise," or 'discipline' - one could even say 'learning.' It certainly does not mean, as some are inclined to think, a willingness to mortify the body that derives from the idea of penance, and even leads to the practice of self-flagellation, since it is believed that one must suffer in order to expiate one's sins. Asceticism is rather a school of the will, a pure heroism (that is, it is disinterested) that Evola, a real expert in this subject, compares to the efforts of a mountain climber. To the layman, mountain climbing may be a pointless effort, but to the climber it is a challenge in which the test of courage, perseverance, and hero-ism is its only purpose. In this we recognize an attitude that Brahmanism knew under certain forms of yoga and Tantrism.

In the spiritual domain, the procedure is the same. Buddha, as we know, was tempted early in his life by a form of asceticism that was similar to that of a hermit living in the desert. This approach involved prolonged fasts and techniques aimed at breaking the body's resistance. Siddhartha, however, realized himself and achieved the Awakening only when he understood this type of asceticism to be a dead end. Turning away from the indignant protests of his early companions, he stopped mortifying his body, ~ Jean Varenne

Nothing was, nothing will be, everything has reality and presence. ~ Hermann Hesse

The landscape of carcinogens is not static either. We are chemical apes: having discovered the capacity to extract, purify, and react molecules to produce new and wondrous molecules, we have begun to spin a new chemical universe around ourselves. Our bodies, our cells, our genes are thus being immersed and reimmersed in a changing flux of molecules
pesticides, pharmaceutical drugs, plastics, cosmetics, estrogens, food products, hormones, even novel forms of physical impulses, such as radiation and magnetism. Some of these, inevitably, will be carcinogenic. We cannot wish this world away; our task, then, is to sift through it vigilantly to discriminate bona fide carcinogens from innocent and useful bystanders. ~ Siddhartha Mukherjee

What a wonderful sleep it had been! Never had sleep so refreshed him, so renewed him, so rejuvenated him! Perhaps he had really died, perhaps he had been drowned and was reborn in another form. No, he recognized himself, he recognized his hands and feet, the place where he lay and the Self in his breast, Siddhartha, self-willed, individualistic. But this Siddhartha was somewhat changed, renewed. He had slept wonderfully. He was remarkably awake, happy and curious. ~ Hermann Hesse

When someone reads a text whose meaning he wants to comprehend, he does not despise the signs and letters, calling them deceptive, contingent, and worthless husks, but rather he reads them, he studies and loves them, letter by letter. But I, the I who wished to read the book of the world and the book of my own essential being, I have, for the sake of a previously imagined meaning, held these signs and letters in contempt, calling the world of appearances deception, calling my eye and my tongue themselves contingent, and worthless appearances. No, this is over, I have awakened, I have indeed awakened, and today is the first day of my new life." --Siddhartha ~ Hermann Hesse

Out of this moment when the world melted away all around him, when he stood alone like a star in the sky, out of this moment of cold and despair, Siddhartha emerged, more himself than before, firmer in his resolve. ~ Hermann Hesse

Cancer's life is a recapitulation of the body's life, its existence a pathological mirror of our own. ~ Siddhartha Mukherjee

In the folklore of science, there is the often-told story of the moment of discovery: the quickening of the pulse, the spectral luminosity of ordinary facts, the overheated, standstill second when observations crystallize and fall together into patterns, like pieces of a kaleidoscope. The apple drops from the tree. The man jumps up from a bathtub; the slippery equation balances itself.
But there is another moment of discovery - its antithesis - that is rarely recorded: the discovery of failure. It is a moment that a scientist often encounters alone. A patient's CT scan shows a relapsed lymphoma. A cell once killed by a drug begins to grow back. A child returns to the NCI with a headache. ~ Siddhartha Mukherjee

(The name vincristine comes from vinca, the Latin word for "bind.") ~ Siddhartha Mukherjee

Technological innovations do not define a science; they merely prove that medicine is scientific - i.e., ~ Siddhartha Mukherjee

I began wondering, can one really write a biography of an illness? But I found myself thinking of cancer as this character that has lived for 4,000 years, and I wanted to know what was its birth, what is its mind, its personality, its psyche? ~ Siddhartha Mukherjee

In Ersilia, to establish the relationships that sustain the city's life, inhabitants stretch strings from the corners of the houses, white or black or gray or black-and-white according to whether they mark a relationship of blood, of trade, authority, agency. When the strings become so numerous that you can no longer pass among them, the inhabitants leave: the houses are dismantled. - Italo Calvino ~ Siddhartha Mukherjee

One swallow is a coincidence, but two swallows make summer. ~ Siddhartha Mukherjee

I could write a thesis on the physiology of vision. But I had no way to look through the fabric of confabulation spun by a man with severe lung disease who was prescribed 'home oxygen', but gave a false address out of embarrassment because he had no 'home.' ~ Siddhartha Mukherjee

I have always thirsted for knowledge, I have always been full of questions. ~ Hermann Hesse

The moral and medical lessons from this story are even more relevant today. Medicine is in the midst of a vast reorganization of fundamental principles. Most of our models of illness are hybrid models; past knowledge is mishmashed with present knowledge. These hybrid models produce the illusion of a systematic understanding of a disease - but the understanding is, in fact, incomplete. Everything seems to work spectacularly, until one planet begins to move backward on the horizon. We have invented many rules to understand normalcy - but we still lack a deeper, more unified understanding of physiology and pathology. ~ Siddhartha Mukherjee

Bill by bill, and letter by letter, his scientific imagination was slowly choked by administrative work. ~ Siddhartha Mukherjee

Yet the personal choice to smoke is ... the same kind of choice as the driver who downed the beers, and then the telephone pole. - Open letter from the tobacco industry, 1988 ~ Siddhartha Mukherjee

If we, as a species, are the ultimate product of Darwinian selection, then so, too, is this incredible disease that lurks inside us. ~ Siddhartha Mukherjee

Science is among the most profoundly human of our activities. Far from being subsumed by the dehumanising effects of technology, science, in fact, remains our last stand against it. ~ Siddhartha Mukherjee

Natures and features last until the grave ~ Siddhartha Mukherjee

Cancer is not one disease but many diseases. ~ Siddhartha Mukherjee

He no longer saw the face of his friend Siddhartha, instead he saw other faces, many, a long sequence, a flowing river of faces, of hundreds, of thousands, which all came and disappeared, and yet all seemed to be there simultaneously, which all constantly changed and renewed themselves, and which were still all Siddhartha. He saw the face of a fish, a carp, with an infinitely painfully opened mouth, the face of a dying fish, with fading eyes - he saw the face of a new-born child, red and full of wrinkles, distorted from crying - he saw the face of a murderer, he saw him plunging a knife into the body of another person - he saw, in the same second, this criminal in bondage, kneeling and his head being chopped off by the executioner with one blow of his sword - he saw the bodies of men and women, naked in positions and cramps of frenzied love - he saw corpses stretched out, motionless, cold, void - he saw the heads of animals, of boars, of crocodiles, of elephants, of bulls, of birds - he saw gods, saw Krishna, saw Agni - he saw all of these figures and faces in a thousand relationships with one another, each one helping the other, loving it, hating it, destroying it, giving re-birth to it, each one was a will to die, a passionately painful confession of transitoriness, and yet none of them died, each one only transformed, was always re-born, received evermore a new face, without any time having passed between the one and the other face - and all of these figures and faces res ~ Hermann Hesse

But he, Siddhartha, was not a source of joy for himself, he found no delight in himself. Walking the rosy paths of the fig tree garden, sitting in the bluish shade of the grove of contemplation, washing his limbs daily in the bath of repentance, sacrificing in the dim shade of the mango forest, his gestures of perfect decency, everyone's love and joy, he still lacked all joy in his heart. Dreams and restless thoughts came into his mind, flowing from the water of the river, sparkling from the stars of the night, melting from the beams of the sun, dreams came to him and a restlessness of the soul, fuming from the sacrifices, breathing forth from the verses of the Rig-Veda, being infused into him, drop by drop, from the teachings of the old Brahmans. ~ Hermann Hesse

On a strange and devious way, Siddhartha had gotten into this final and most base of all dependencies, by means of the game of dice. It was since that time, when he had stopped being a Samana in his heart, that Siddhartha began to play the game for money and precious things, which he at other times only joined with a smile and casually as a custom of the childlike people, with an increasing rage and passion. He was a feared gambler, few dared to take him on, so high and audacious were his stakes. He played the game due to a pain of his heart, losing and wasting his wretched money in the game brought him an angry joy, in no other way he could demonstrate his disdain for wealth, the merchants' false god, more clearly and more mockingly. ~ Hermann Hesse

Surely," Siddhartha laughed, "surely I have travelled for my amusement. For what else? I have gotten to know people and places, I have received kindness and trust, I have found friendship. Look, my dear, if I had been Kamaswami, I would have travelled back, being annoyed and in a hurry, as soon as I had seen that my purchase had been rendered impossible, and time and money would indeed have been lost. But like this, I've had a few good days, I've learned, had joy, I've neither harmed myself nor others by annoyance and hastiness. And if I'll ever return there again, perhaps to buy an upcoming harvest, or for whatever purpose it might be, friendly people will receive me in a friendly and happy manner, and I will praise myself for not showing any hurry and displeasure at that time. So, leave it as it is, my friend, and don't harm yourself by scolding! If the day will come, when you will see: this Siddhartha is harming me, then speak a word and Siddhartha will go on his own path. But until then, let's be satisfied with one another. ~ Hermann Hesse

It felt - nearly twenty-five hundred years after Hippocrates had naively coined the overarching term karkinos - that modern oncology was hardly any more sophisticated in its taxonomy of cancer. ~ Siddhartha Mukherjee

Whether it is good or evil, whether life in itself is pain or pleasure, whether it is uncertain-that it may perhaps be this is not important-but the unity of the world, the coherence of all events, the embracing of the big and the small from the same stream, from the same law of cause, of becoming and dying. ~ Hermann Hesse

Cancer is a tremendous opportunity to have your face pressed right up against the glass of your mortality. But what patients see through the glass is not a world outside cancer, but a world taken over by it - cancer reflected endlessly around them like a hall of mirrors. ~ Siddhartha Mukherjee

In an essay titled A View From the Front Line, Jencks described her experience with cancer as like being woken up midflight on a jumbo jet and then thrown out with a parachute into a foreign landscape without a map:
"There you are, the future patient, quietly progressing with other passengers toward a distant destination when, astonishingly (Why me?) a large hole opens in the floor next to you. People in white coats appear, help you into a parachute and - no time to think - out you go.
"You descend. You hit the ground ... But where is the enemy? What is the enemy? What is it up to? ... No road. No compass. No map. No training. Is there something you should know and don't?
"The white coats are far, far away, strapping others into their parachutes. Occasionally they wave but, even if you ask them, they don't know the answers. They are up there in the Jumbo, involved with parachutes, not map-making. ~ Siddhartha Mukherjee

You will learn it," spoke Vasudeva, "but not from me. The river has taught me to listen, from it you will learn it as well. The river knows everything, everything can be learned from it. See, you've already learned this from the water too, that it is good to strive downwards, to sink, to seek depth. The rich and elegant Siddhartha is becoming an oarsman's servant, the learned Brahmin Siddhartha becomes a ferryman: this has also been told to you by the river. You'll learn that other thing from it as well." Siddhartha ~ Hermann Hesse

Siddhartha had one single goal before him -- to become empty, empty of thirst, empty of desire, empty of dreams, empty of joy and sorrow. To die away from himself, no longer to be "I," to find the peace of an empty heart, to be open to wonder within an egoless mind -- that was his goal. When every bit of ego was overcome and dead, when in his heart all cravings and compulsions had been stilled, then the ultimate must awaken, that innermost essence in one's being that is no longer ego, the great mystery. ~ Hermann Hesse

Leukemia was a malignant proliferation of white cells in the blood. It was cancer in a molten, liquid form. ~ Siddhartha Mukherjee

Vasudeva listened with great attention. Listening carefully, he let
everything enter his mind, birthplace and childhood, all that learning,
all that searching, all joy, all distress. This was among the
ferryman's virtues one of the greatest: like only a few, he knew how
to listen. Without him having spoken a word, the speaker sensed how
Vasudeva let his words enter his mind, quiet, open, waiting, how he
did not lose a single one, awaited not a single one with impatience,
did not add his praise or rebuke, was just listening. Siddhartha felt,
what a happy fortune it is, to confess to such a listener, to burry in
his heart his own life, his own search, his own suffering. ~ Hermann Hesse

Most of the selected essays share a common thread: They describe how science happens. ~ Siddhartha Mukherjee

And so Gotama wandered into the town to obtain alms, and the two Samanas recognized him only by his complete peacefulness of demeanor, by the stillness of his form, in which there was no seeking, no will, no counterfeit, no effort - only light and peace. ~ Hermann Hesse

If you take 100 breast-cancer samples, 100 types of cancer have 100 different hallmarks of mutated genes. You could be nihilistic and say, 'Oh, God, we'll never be able to tackle this!' But there are deep, systematic, organizational principles at work in all that diversity. ~ Siddhartha Mukherjee

If something is good, more is not necessarily better. Not always. ~ Siddhartha Mukherjee

in BRCA-1 has a 50 to 80 percent chance of developing breast cancer in her lifetime (the gene also increases the risk for ovarian cancer), about three to five times the normal risk. ~ Siddhartha Mukherjee

I think the way we think about cancer, the way we treat cancer, has dramatically changed in the last century. There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients or providing patients with psychic solace or pain relief. ~ Siddhartha Mukherjee

Cancer is not a concentration camp, but it shares the quality of annihilation: it negates the possibility of life outside and beyond itself; it subsumes all living. ~ Siddhartha Mukherjee

There was no detectable association between gliomas and cell phone use overall. Prevention experts, and phone-addicted teenagers, may have rejoiced - but only briefly. ~ Siddhartha Mukherjee

Cell culture is a little like gardening. You sit and you look at cells, and then you see something and say, 'You know, that doesn't look right'. ~ Siddhartha Mukherjee

Our encounter with cancer has rounded us off; it has smoothed and polished us like river rocks. ~ Siddhartha Mukherjee

It was, I suspected, not the first time that a patient had consoled a doctor about the ineffectuality of his discipline. ~ Siddhartha Mukherjee

Thinking, he walked ever more slowly and asked himself, What is it now that you were hoping to learn from doctrines and teachers, and what is it that they - who taught you so much - were unable to teach you? And, he decided, It was the Self whose meaning and nature I wished to learn. It was the Self I wished to escape from, wished to overcome. But I was unable to overcome it, I could only trick it, could only run away from it and hide. Truly, not a single thing in all the world has so occupied my thoughts as this Self of mine, this riddle: that I am alive and that I am One, am different and separate from all others, that I am Siddhartha! And there is not a thing in the world about which I know less than about myself, about Siddhartha! ~ Hermann Hesse

Govinda was standing in front of him, dressed in the yellow robe of an ascetic. Sad was how Govinda looked like, sadly he asked: Why have you forsaken me? At this, he embraced Govinda, wrapped his arms around him, and as he was pulling him close to his chest and kissed him, it was not Govinda any more, but a woman, and a full breast popped out of the woman's dress, at which Siddhartha lay and drank, sweetly and strongly tasted the milk from this breast. ~ Hermann Hesse

What does it mean to be an oncologist? It means that you get to sit in at a moment of another person's life that is so hyper-acute, and not just because they're medically ill. It's also a moment of hope and expectation and concern. ~ Siddhartha Mukherjee

Unidentified flying objects, abominable snowmen, the Loch Ness monster and human cancer viruses. - Medical World News, 1974, on four "mysteries" widely reported and publicized but never seen ~ Siddhartha Mukherjee

Cancer, perhaps, is an ultimate perversion of genetics - a genome that becomes pathologically obsessed with replicating itself. The ~ Siddhartha Mukherjee

A goal stood before Siddhartha, a single goal: to become empty, empty of thirst, empty of wishing, empty of dreams, empty of joy and sorrow. Dead to himself, not to be a self any more, to find tranquility with an emptied heard, to be open to miracles in unselfish thoughts, that was his goal. Once all of my self was overcome and had died, once every desire and every urge was silent in the heart, then the ultimate part of me had to awake, the innermost of my being, which is no longer my self, the great secret. ~ Hermann Hesse

Siddhartha considered the ways of the demon, and in that moment he struck. ~ Roger Zelazny

But the pigs--seventy pounds of porcine weight that did not take kindly to weekly endoscopies--did not sprout any ulcers. And testing the theory on humans was ethically impossible: how could one justify infecting a human with a new, uncharacterized species of bacteria to prove that it caused gastritis and predisposed to cancer?
In July 1984, with his experiments stalled and his grant applications in jeopardy, Marshall performed the ultimate experiment: "On the morning of the experiment, I omitted my breakfast….Two hours later, Neil Noakes scraped a heavily inoculated 4 day culture plate of Helicobacter and dispersed the bacteria in alkaline peptone water (a kind of meat broth used to keep bacteria alive). I fasted until 10 am when Neil handed me a 200 ml beaker about one quarter full of the cloudy brown liquid. I drank it down in one gulp then fasted for the rest of the day. A few stomach gurgles occurred. Was it the bacteria or was I just hungry? ~ Siddhartha Mukherjee

The trial designed to bring the most rigorous statistical analysis to the cause of lung cancer barely required elementary mathematics to prove its point. ~ Siddhartha Mukherjee

Siddhartha saw it hurrying, the river, which consisted of him and his loved ones and of all people, he had ever seen, all of these waves and waters were hurrying, suffering, towards goals, many goals, the waterfall, the lake, the rapids, the sea, and all goals were reached, and every goal was followed by a new one, and the water turned into vapour and rose to the sky, turned into rain and poured down from the sky, turned into a source, a stream, a river, headed forward once again, flowed on once again. ~ Hermann Hesse

It is encrusted with history. Embedded within it are peculiar fragments of DNA-some derived from ancient viruses-that were inserted into the genome in the distant past and have been carried passively for millennia since then. Some of these fragments were once capable of actively "jumping" between genes and organisms, but they have now been largely inactivated and silenced. Like decommissioned traveling salesmen, these pieces are permanently tethered to our genome, unable to move or get out. These fragments are vastly more common than genes, resulting in yet another major idiosyncrasy of our genome: much of the human genome is not particularly human. ~ Siddhartha Mukherjee

You were willing. See here, Kamala: When you throw a stone into water, it falls quickly by the fastest route to the bottom of the pond. This is the way it is when Siddhartha has an aim, an intention. Siddhartha does nothing - he waits, he thinks, he fasts - but he passes through the things of the world like the stone through the water, without bestirring himself. He is drawn forward and he lets himself fall. His goal draws him to it, for he lets nothing enter his mind that interferes with the goal. This is what Siddhartha learned from the shramanas. This is what fools call magic, thinking that it is brought about by demons. Nothing is brought about by demons; demons do not exist. Anyone can do magic, anyone can reach his goals if he can think, wait, and fast. ~ Hermann Hesse

Every era casts illness in its own image. Society, like the ultimate psychosomatic patient, matches its medical afflictions to its psychological crises; when a disease touches such a visceral chord, it is often because that chord is already resonating. ~ Siddhartha Mukherjee

Cancer begins and ends with people. In the midst of scientific abstraction, it is sometimes possible to forget this one basic fact. ... ~ Siddhartha Mukherjee

As children, Siddhartha and Jesus both realized that life is filled with suffering. The Buddha became aware at an early age that suffering is pervasive. Jesus must have had the same kind of insight, because they both made every effort to offer a way out. We, too, must learn to live in ways that reduce the world's suffering. ~ Nhat Hanh

When someone is searching," said Siddhartha, "then it might easily happen that the only thing his eyes still see is that what he searches for, that he is unable to find anything, to let anything enter his mind, because he always thinks of nothing but the object of his search, because he has a goal, because he is obsessed by the goal. Searching means: having a goal. But finding means: being free, being open, having no goal. You, oh venerable one, are perhaps indeed a searcher, because, striving for your goal, there are many things you don't see, which are directly in front of your eyes. ~ Hermann Hesse

Slowly blossomed, slowly ripened in Siddhartha the realisation, the knowledge, what wisdom actually was, what the goal of his long search was. It was nothing but a readiness of the soul, an ability, a secret art, to think every moment, while living his life, the thought of oneness, to be able to feel and inhale the oneness. ~ Hermann Hesse

Within Siddhartha there slowly grew and ripened the knowledge of what wisdom really was and the goal of his long seeking. It was nothing but a preparation of the soul, a capacity, a secret art of thinking, feeling and breathing thoughts of unity at every moment of life. ~ Hermann Hesse

In the art of love," she said thoughtfully, "you are the best I've ever seen. You are stronger than others, more agile, more willing. Well have you learned my art, Siddhartha. Some day, when I am older, I wish to bear your child. And yet all this time, beloved, you have remained a Samana. Even now you do not love me; you love no one. Is it not so?" "It may be so," Siddhartha said wearily. "I am like you. You, too, do not love - how else could you practice love as an art? Perhaps people of our sort are incapable of love. The child people can love; that is their secret. ~ Hermann Hesse

Medicine, I said, begins with storytelling. Patients tell stories to describe illness; doctors tell stories to understand it. Science tells its own story to explain diseases. ~ Siddhartha Mukherjee

Siddhartha is a dead man and a living ideal. The man taught about overcoming pain, and influencing one's future reincarnations. "But I pray to the ideal. ~ David Mitchell

The search for a way to eradicate this scourge ... is left to incidental dabbling and uncoordinated research. - The Washington Post, 1946 ~ Siddhartha Mukherjee

They both listened silently to the water, which to them was not just water, but the voice of life, the voice of Being, the voice of perpetual Becoming. ~ Hermann Hesse

I'm human, we all are - all doctors are - and grieving is a natural part of medicine. As a doctor, grieving is a natural part of medicine. If you deny that, again, you'd get into this trap of curing and victory. I think grief is very important. ~ Siddhartha Mukherjee

Science is often described as an iterative and cumulative process, a puzzle solved piece by piece, with each piece contributing a few hazy pixels of a much larger picture. But the arrival of a truly powerful new theory in science often feels far from iterative. Rather than explain one observation or phenomenon in a single, pixelated step, an entire field of observations suddenly seems to crystallize into a perfect whole. The effect is almost like watching a puzzle solve itself. ~ Siddhartha Mukherjee

You spent all this money to save mice the problem of developing tumors? Exchanges ~ Siddhartha Mukherjee

Bailey had profoundly changed the conversation around sexual identity away from the 1960s rhetoric of "choice" and "personal preference" toward biology, genetics, and inheritance. If we did not think of variations in height or the development of dyslexia or type 1 diabetes as choices, then we could not think of sexual identity as a choice. But ~ Siddhartha Mukherjee

The universe seeks equilibriums; it prefers to disperse energy, disrupt organization, and maximize chaos. Life is designed to combat these forces. We slow down reactions, concentrate matter, and organize chemicals into compartments; we sort laundry on Wednesdays. "It sometimes seems as if curbing entropy is our quixotic purpose in the universe," James Gleick wrote. We live in the loopholes of natural laws, seeking extensions, exceptions and excuses. The laws of nature still mark the outer boundaries of permissibility - but life, in all its idiosyncratic, mad weirdness, flourishes by reading between the lines. ~ Siddhartha Mukherjee

Those who have not been trained in chemistry201 or medicine may not realize how difficult the problem of cancer treatment really is. It is almost - not quite, but almost - as hard as finding some agent that will dissolve away the left ear, say, and leave the right ear unharmed. So slight is the difference between the cancer cell and its normal ancestor. - William Woglom Life ~ Siddhartha Mukherjee

Ehrlich hedged. The cancer cell, he explained, was a fundamentally different target from a bacterial cell. Specific affinity relied, paradoxically, not on "affinity," but on its opposite - on difference. Ehrlich's chemicals had successfully targeted bacteria because bacterial enzymes were so radically dissimilar to human enzymes. With cancer, it was the similarity of the cancer cell to the normal human cell that made it nearly impossible to target. ~ Siddhartha Mukherjee

Kamaswami conducted his business with care and often with passion, but Siddhartha looked upon all of this as if it was a game, the rules of which he tried hard to learn precisely, but the contents of which did not touch his heart. ~ Hermann Hesse

Illness might progressively vanish so might identity. Grief might be diminished, but so might tenderness. Traumas might be erased but so might history. Infirmities might disappear, but so might vulnerability. Chance would become mitigated, but so, inevitably, would choice. ~ Siddhartha Mukherjee

Cancer has enormous diversity and behaves differently: it's highly mutable, the evolutionary principles are very complicated and often its capacity to be constantly mystifying comes as a big challenge. ~ Siddhartha Mukherjee