Human Genome Quotes

When I discover something about the human genome, I experience a sense of awe at the mystery of life, and say to myself, 'Wow, only God knew before.' It is a profoundly beautiful and moving sensation, which helps me appreciate God and makes science even more rewarding for me. ~ Francis Collins

Raises a fundamental question: are we also evolving genetically? Medical research, added to a deepening analysis of the three billion nucleotide letters of the human genome, has revealed that evolution is indeed still occurring ~ Edward O. Wilson

I would only once have the opportunity to let my scientific career encompass a path from the double helix to the three billion steps of the human genome. ~ James D. Watson

The brain is the most complicated organ in the universe. We have learned a lot about other human organs. We know how the heart pumps and how the kidney does what it does. To a certain degree, we have read the letters of the human genome. But the brain has 100 billion neurons. Each one of those has about 10,000 connections. ~ Francis Collins

Elon is one of the few people that I feel is more accomplished than I am," said Craig Venter, the man who decoded the human genome and went on to create synthetic lifeforms. At some point he hopes to work with Musk on a type of DNA printer that could be sent to Mars. It would, in theory, allow humans to create medicines, food, and helpful microbes for early settlers of the planet. "I think biological teleportation is what is going to truly enable the colonization of space," he said. "Elon and I have been talking about how this might play out. ~ Ashlee Vance

The human genome will not help us to understand the spiritual side of humankind, or to know who God is or what love is. The well-heeled couple who decide they want to use genetics to have a child that is a gifted musician may end up with a sullen adolescent who smokes marijuana and doesn't talk to them. ~ Francis Collins

About 1.2% of the human genome is made up of genes, things that encode for proteins, the stuff that we consider us. There is about 8.3% that's a virus. In other words we're probably about seven times more virus than we are human genes, which is kind of a weird way to thinking about yourself. ~ Carl Zimmer

The human genome is a script, waiting for the amino actors, the protein players to strut and fret their hour. ~ Johnny Rich

The decoding of the human genome tells us that we are indeed related to the animals, the insects, and the plants, and that, like it or not, Earth is where we belong. ~ Ian McCallum

As was predicted at the beginning of the Human Genome Project, getting the sequence will be the easy part as only technical issues are involved. The hard part will be finding out what it means, because this poses intellectual problems of how to understand the participation of the genes in the functions of living cells. ~ Sydney Brenner

As the leader of the international Human Genome Project, which had labored mightily over more than a decade to reveal this DNA sequence, I stood beside President Bill Clinton in the East Room of the White House...

Clinton's speech began by comparing this human sequence map to the map that Meriwether Lewis had unfolded in front of President Thomas Jefferson in that very room nearly two hundred years earlier.

Clinton said, "Without a doubt, this is the most important, most wondrous map ever produced by humankind." But the part of his speech that most attracted public attention jumped from the scientific perspective to the spiritual. "Today," he said, "we are learning the language in which God created life. We are gaining ever more awe for the complexity, the beauty, and the wonder of God's most divine and sacred gift."

Was I, a rigorously trained scientist, taken aback at such a blatantly religious reference by the leader of the free world at a moment such as this? Was I tempted to scowl or look at the floor in embarrassment? No, not at all. In fact I had worked closely with the president's speechwriter in the frantic days just prior to this announcement, and had strongly endorsed the inclusion of this paragraph.

When it came time for me to add a few words of my own, I echoed this sentiment: "It's a happy day for the world. It is humbling for me, and awe-inspiring, to realize that we have caught the first glimpse of our own instruct ~ Francis S. Collins

It is encrusted with history. Embedded within it are peculiar fragments of DNA-some derived from ancient viruses-that were inserted into the genome in the distant past and have been carried passively for millennia since then. Some of these fragments were once capable of actively "jumping" between genes and organisms, but they have now been largely inactivated and silenced. Like decommissioned traveling salesmen, these pieces are permanently tethered to our genome, unable to move or get out. These fragments are vastly more common than genes, resulting in yet another major idiosyncrasy of our genome: much of the human genome is not particularly human. ~ Siddhartha Mukherjee

There is no real reason why Disney should not buy up the human genome, which is currently being sequenced, to turn it into a genetic attraction. Why not cryogenize the whole planet, exactly as Walt Disney had himself cryogenized in liquid nitrogen, with a view to some kind of resurrection or other in the real world? But there no longer is a real world, and there won't be one – not even for Walt Disney: if he wakes up one day he'll get the shock of his life. In the meantime, from the depths of his liquid nitrogen he goes on annexing the world – both imaginary and real – subsuming it into the spectral universe of virtual reality in which we have all become extras. The difference is that, as we slip on our data suits or our sensors, or tap away at our keyboards, we are moving into living spectrality, whereas he, the brilliant precursor, has moved into the virtual reality of death. ~ Jean Baudrillard

Consider: The human genome consists of about 3.3 billion base pairs. Since there are only four types of pair, that amounts to 0.8 gigabytes of information, or about what you can fit on a CD. With a microwave radio transmitter, you could beam that amount of information into space in a few minutes, and have it travel to anyone at light speed. ~ Seth Shostak

I respect and value the ideals of rugged individualism and self-reliance. But rugged individualism didn't defeat the British, it didn't get us to the moon, build our nation's highways, or map the human genome. We did that together. This is the high call of patriotism. ~ Cory Booker

I celebrate ideals of individual excellence, self-reliance, and personal responsibility… But rugged individualism alone did not get us to the moon. It did not end slavery, win World War II, pass the Voting Rights Act, or bring down the Berlin Wall. It didn't build our dams, bridges, and highways, or map the human genome. Our most lasting accomplishments require mutual effort and shared sacrifice; this is an idea that is woven into the very fabric of this country. ~ Cory Booker

It appears that the human genome does indeed contain deserts, or large, gene-poor regions. ~ Craig Venter

I'm fascinated with genetic science, and I have been for a very long time. I always look at science and technology because I think that the developments in my lifetime have been so remarkable - and we're only at the tip of the iceberg with projects like decoding the human genome. ~ Nick Rhodes

If you're looking for your own idea of your own identity you know the human genome may not be the best place to look for it. You're just looking at a bunch of viruses. ~ Carl Zimmer

The beauty in the genome is of course that it's so small. The human genome is only on the order of a gigabyte of data ... which is a tiny little database. If you take the entire living biosphere, that's the assemblage of 20 million species or so that constitute all the living creatures on the planet, and you have a genome for every species the total is still about one petabyte, that's a million gigabytes - that's still very small compared with Google or the Wikipedia and it's a database that you can easily put in a small room, easily transmit from one place to another. And somehow mother nature manages to create this incredible biosphere, to create this incredibly rich environment of animals and plants with this amazingly small amount of data. ~ Freeman Dyson

As a Christian, but also as a scientist responsible for overseeing the Human Genome Project, one of my concerns has been the limits on applications of our understanding of the genome. Should there be limits? I think there should. I think the public has expressed their concern about ways this information might be misused. ~ Francis Collins

I'm hoping that these next 20 years will show what we did 20 years ago in sequencing the first human genome, was the beginning of the health revolution that will have more positive impact in people's lives than any other health event in history. ~ Craig Venter

Soon after Harris's HeLa-chicken study, a pair of researchers at New York University discovered that human-mouse hybrids lost their human chromosomes over time, leaving only the mouse chromosomes. This allowed scientists to begin mapping human genes to specific chromosomes by tracking the order in which genetic traits vanished. If a chromosome disappeared and production of a certain enzyme stopped, researchers knew the gene for that enzyme must be on the most recently vanished chromosome. Scientists in laboratories throughout North America and Europe began fusing cells and using them to map genetic traits to specific chromosomes, creating a precursor to the human genome map we have today. ~ Rebecca Skloot

I would like to do a series about sequencing the human genome, and also analyze more human diversity among other ethnic groups - a 'Faces of America 2.' ~ Henry Louis Gates

Read the book of life or a life in a book: it's all epigraphs and anagrams. ~ Johnny Rich

The human genome is made up of some 20,300 genes. Out of which 736 genes are associated with temperament, a total of 709 related to general cognitive functions, 148 genes are related to higher cognitive functions and 48 genes are associated with deep meditation and 8 genes are related to witnessing consciousness. ~ Amit Ray

If Marx came back to life today, he would probably urge his few remaining disciples to devote less time to reading Das Kapital and more time to studying the Internet and the human genome. ~ Yuval Noah Harari

I don't know why we keep building these fucking dams," Adams said in a surprisingly forceful British whisper. "Not only do they cause environmental and social disasters, they, with very few exceptions, all fail to do what they were supposed to do in the first place. Look at the Amazon, where they've all silted up. What is the reaction to that? They're going to build another eighty of them. It's just balmy. We must have beaver genes or something ... There's just this kind of sensational desire to build dams, and maybe that should be looked at and excised from human nature. Maybe the Human Genome Project can locate the beaver/dam-building gene and cut that out. ~ Douglas Adams

History repeats itself, in part because the genome repeats itself. And the genome repeats itself, in part because history does. The impulses, ambitions, fantasies, and desires that drive human history are, at least in part, encoded in the human genome. And human history has, in turn, selected genomes that carry these impulses, ambitions, fantasies, and desires. This self-fulfilling circle of logic is responsible for some of the most magnificent and evocative qualities in our species, but also some of the most reprehensible. It is far too much to ask ourselves to escape the orbit of this logic, but recognizing its inherent circularity, and being skeptical of its overreach, might protect the week from the will of the strong, and the 'mutant' from being annihilated by the 'normal'. ~ Siddhartha Mukherjee

If we can put a man on the moon and sequence the human genome, we should be able to devise something close to a universal digital public library. ~ Peter Singer

Evolutionary biologist Ryan Gregory put it, anyone who thinks he or she can assign a function to every letter in the human genome should be asked why an onion needs a genome that is about five times larger than a person's. Who's resorting ~ Matt Ridley

Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria's effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What's more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so. ~ Michael J. Behe

The very genetic determinism I posited in World's End as a way of shaking off my inherited demons is being proven in fact as we map out the human genome. ~ T.C. Boyle

The overall view of the human genome project has been one of great excitement and positive press, but there are people who have concerns that are quite reasonable, and they are frightened of things they don't understand. ~ Thomas R. Cech

In 2006, the Vogelstein team revealed the first landmark sequencing effort by analyzing thirteen thousand genes in eleven breast and colon cancers. (Although the human genome contains about twenty thousand genes in total, Vogelstein's team initially had tools to assess only thirteen thousand.) In 2008, both Vogelstein's group and the Cancer Genome Atlas consortium extended this effort by sequencing hundreds of genes of several dozen specimens of brain tumors. As of 2009, the genomes of ovarian cancer, pancreatic cancer, melanoma, lung cancer, and several forms of leukemia have been sequenced, revealing the full catalog of mutations in each tumor type. Perhaps ~ Siddhartha Mukherjee

Before the Human Genome Project, most scientists assumed, based on our complex brains and behaviors, that humans must have around 100,000 genes; some estimates went as high as 150,000. ~ Sam Kean

Once a genetic component has been established, the search for the genes involved can begin. This is a time-consuming and complex process that has recently been greatly facilitated by the information obtained by the Human Genome Project.51 ~ Joseph E. Ledoux

When results are shared freely amongst the biological community, as has been done for the worm and the Human Genome Projects, specialist scientists can move much more rapidly towards their goals. ~ John Sulston

In Lewis Carroll's poem, when the hunters finally capture the deceptive Snark, it reveals itself not to be a foreign beast, but one of the human hunters sent to trap it. And so it had turned out with cancer. Cancer genes came from within the human genome. Indeed the Greeks had been peculiarly prescient yet again in their use of the term oncos. Cancer was intrinsically "loaded" in our genome. ~ Siddhartha Mukherjee

Sometimes it is claimed by those who argue that race is just a social construct that the human genome project shows that because people share roughly 99% of their genes in common, that there are no races. This is silly. ~ J. Philippe Rushton

The human genome is a life written in a book where every word has been written before. A story endlessly rehearsed. ~ Johnny Rich

Introns are not the exception in human genes; they are the rule. Human introns are often enormous-spanning several hundreds of thousands of bases of DNA. And genes themselves are separated from each other by long stretches of intervening DNA, called intergenic DNA. Intergenic DNA and introns-spaces between genes and stuffers within genes-are though to have sequences that allow genes to be regulated in context. To return to our analogy; these regions might be described as long ellipses scattered with occasional punctuation marks. The human genome can thus be visualized as:

This......is............the......(...)...s...truc...ture......of......your......gen...om...e;

The words represent genes. The long ellipses between the words represent the stretches of intergenic DNA. The shorter ellipses within the words (gen...ome...e) are introns. The parentheses and semicolons-punctuation marks-are regions of DNA that regulate genes. ~ Siddhartha Mukherjee

Solidarity with local communities lies at the heart of culture-centered public relations because it seeks to co-create local narratives that have otherwise been erased from the mainstream public spheres (de Sousa Santos, Nunes, and Meneses, 2008). Local voices offer entry points for co-creating narratives that have otherwise been erased. It is through the re-appropriation of the community as a site of resistance as opposed to a site of neoliberal governance that new meaning structures are articulated (Beverly, 2004a,b; Spivak, 1988a,b; Tihuwai Smith, 2006). It is through these new meanings narrated at local community levels that the scientific modernist discourses of neoliberalism are disrupted. For instance, to the large-scale funding of the Human Genome Diversity Project (HGDP) with the goal of mapping ~ Krishnamurthy Sriramesh

Even if we never cure a single disease, the Human Genome Project and other ventures will have been worth it. ~ Sam Kean

How does the body push the comparatively tiny genome so far? Many researchers want to put the weight on learning and experience, apparently believing that the contribution of the genes is relatively unimportant. But though the ability to learn is clearly one of the genome's most important products, such views overemphasize learning and significantly underestimate the extent to which the genome can in fact guide the construction of enormous complexity. If the tools of biological self-assembly are powerful enough to build the intricacies of the circulatory system or the eye without requiring lessons from the outside world, they are also powerful enough to build the initial complexity of the nervous system without relying on external lessons.

The discrepancy melts away as we appreciate the true power of the genome. We could start by considering the fact that the currently accepted figure of 30,000 could well prove to be too low. Thirty thousand (or thereabouts) is, at press time, the best estimate for how many protein-coding genes are in the human genome. But not all genes code for proteins; some, not counted in the 30,000 estimate, code for small pieces of RNA that are not converted into proteins (called microRNA), of "pseudogenes," stretches of DNA, apparently relics of evolution, that do not properly encode proteins. Neither entity is fully understood, but recent reports (from 2002 and 2003) suggest that both may play some role in the all-important process of regul ~ Gary F. Marcus

Art is that imaginative expression of human energy, which, through technical concretion of feeling and perception, tends to reconcile the individual with the universal, by exciting in him impersonal emotion. And the greatest Art is that which excites the greatest impersonal emotion in an hypothetical perfect human being.

Impersonal emotion! And what - I thought - do I mean by that? Surely I mean: That is not Art, which, while I am contemplating it, inspires me with any active or direct impulse; that is Art, when, for however brief a moment, it replaces within me interest in myself by interest in itself. For, let me suppose myself in the presence of a carved marble bath. If my thoughts be: 'What could I buy that for?' Impulse of acquisition; or: 'From what quarry did it come?' Impulse of inquiry; or: 'Which would be the right end for my head?' Mixed impulse of inquiry and acquisition - I am at that moment insensible to it as a work of Art. But, if I stand before it vibrating at sight of its colour and forms, if ever so little and for ever so short a time, unhaunted by any definite practical thought or impulse - to that extent and for that moment it has stolen me away out of myself and put itself there instead; has linked me to the universal by making me forget the individual in me. And for that moment, and only while that moment lasts, it is to me a work of Art. The word 'impersonal,' then, is but used in this my definition to signify momentary forgetfulness of one' ~ John Galsworthy

You have such an odd relationship to your environment," mused the man. "Such a paranoid relationship. You seem intent on existing in smaller and smaller spaces, filled with more and more gadgets, with the mistaken impression that this will give you more control over your lives. There's something a little impious about it."
"Nothing wrong with gadgets," muttered Alif.
"No, except that they're not magic," said the man, "and a lot of you seem to believe they should be. ~ G. Willow Wilson

I never pick up an item without thinking of how I might improve it. I never perfected an invention that I did not think about in terms of the service it might give others. I want to save and advance human life, not destroy it. I am proud of the fact that I never invented weapons to kill. The dove is my emblem. ~ Thomas A. Edison

[You have Rights] antecedent to all earthly governments: Rights, that cannot be repealed or restrained by human laws; Rights, derived from the Great Legislator of the universe. ~ John Adams

I write in order to understand the images. Being what my agent ... somewhat ruefully calls a language playwright, is problematic because in production, you have to make the language lift off the page. But a good actor can turn it into human speech. I err sometimes toward having such a compound of images that if an actor lands heavily on each one, you never pull through to a larger idea. That's a problem for the audience. But I come to playwriting from the visual world - I used to be a painter. I also really love novels and that use of language. But it's tricky to ask that of the theatre. ~ Ellen McLaughlin

What You Should Know to be a Poet"

all you can know about animals as persons.
the names of trees and flowers and weeds.
the names of stars and the movements of planets
and the moon.
your own six senses, with a watchful elegant mind.
at least one kind of traditional magic:
divination, astrology, the book of changes, the tarot;

dreams.
the illusory demons and the illusory shining gods.
kiss the ass of the devil and eat sh*t;
fuck his horny barbed cock,
fuck the hag,
and all the celestial angels
and maidens perfum'd and golden-

& then love the human: wives husbands and friends
children's games, comic books, bubble-gum,
the weirdness of television and advertising.

work long, dry hours of dull work swallowed and accepted
and lived with and finally lovd. exhaustion,
hunger, rest.

the wild freedom of the dance, extasy
silent solitary illumination, entasy

real danger. gambles and the edge of death. ~ Gary Snyder

Be wary, though, of the way news media use the word "significant," because to statisticians it doesn't mean "noteworthy." In statistics, the word "significant" means that the results passed mathematical tests such as t-tests, chi-square tests, regression, and principal components analysis (there are hundreds). Statistical significance tests quantify how easily pure chance can explain the results. With a very large number of observations, even small differences that are trivial in magnitude can be beyond what our models of change and randomness can explain. These tests don't know what's noteworthy and what's not - that's a human judgment. ~ Daniel J. Levitin

The way people in the United States execute human beings would not pass muster for euthanasia of animals. ~ Jamie Fellner

It's deeply human to do both the worst things and the best things because of your fear of loss. ~ Cass Sunstein

Happily, I am not human, Parinherm thought, and this is only a simulation. ~ Iain M. Banks

Have patience with all things but first with yourself. Never confuse your mistakes with your value as a human being. You are perfectly valuable, creative, worthwhile person simply because you exist. And no amount of triumphs or tribulations can ever change that. ~ Saint Frances De Sales

There are many things which can not be expressed by words.
There are many words which can not be spelled by human tongue.
There are many tongues which utter one single truth. ~ Toba Beta

We don't even survive in the memories of the living. Science has destroyed that myth. Whenever we remember something, what we're doing is remembering the last time we remembered it; our memory doesn't go back to the original notch, the first one was cut, but to the last one. Human memory is virtual, like that of a computer. When we open a file we're not opening it as it was when we first created it, but as it was the last time we used it. It is called hypercathexis and is our brain's most sophisticated recourse when it comes to confronting pain. ~ Enrique De Heriz

The Saudis have never shown any respect for human rights, either now or in the past. Even a petty burglar faces having one of his hands chopped off. The liberal press in America prefers to ignore all this, although they don't hesitate to blacken the reputation of Iran. ~ Mohammed Reza Pahlavi

Politics is a matter of human transaction. I consider absolutely everything political, because all fiction involves relationships between people, and relationships between people always include matters of power, of equity, of communication. ~ Deborah Eisenberg

It is not human nature to enjoy what we get with no effort. ~ Sri Chinmoy

If the third dimension and perceptions of sacredness are an important part of human nature, then the scientific community should accept religiosity as a normal and healthy aspect of human nature - an aspect that is as deep, important, and interesting as sexuality or language (which we study intensely). Here's another treasonous thought: If religious people are right in believing that religion is the source of their greatest happiness, then maybe the rest of us who are looking for happiness and meaning can learn something from them, whether or not we believe in God. That's the topic of the final chapter. ~ Jonathan Haidt

Humanity is identity. All men are made of the same clay. No difference, here below at least, in predestination. The same darkness before, the same flesh during, the same ashes after. But when ignorance is mixed with human dough, it blackens it. This incurable blackness takes over man's insides and there turns into evil ... Destroy the dark hold, Ignorance, and you destroy the mole, Crime. ~ Victor Hugo

The mature man lives quietly, does good privately, takes responsibility for his actions, treats others with friendliness and courtesy, finds mischief boring and avoids it. Without the hidden conspiracy of goodwill, society would not endure an hour. ~ Kenneth Rexroth

As things are now going, the peace we will make, the peace we seem to be making, will be a peace of oil, a peace of gold, a peace of shipping, a peace, in brief ... without moral purpose or human interest. ~ Archibald MacLeish

Here is Senator Russell in a colloquy on the Senate floor with Senator Proxmire: There is something about preparing for destruction that causes men to be more careless in spending money than they would be if they were building for constructive purposes. Why that is so I do not know; but I have observed, over a period of almost thirty years in the Senate, that there is something about buying arms with which to kill, to destroy, to wipe out cities, and to obliterate great transportation systems which causes men not to reckon the dollar cost as closely as they do when they think about proper housing and the care of the health of human beings. ~ Paul A. Baran

Technology is unlocking the innate compassion we have for our fellow human beings. ~ Bill Gates

Talk to ourselves in the same way we'd talk to someone we'd love. Yes, you made a mistake. You're human. You don't have to do it like anyone else does. Fixing it and making amends will help. Self-loathing will not. Reach out to someone we trust--a person who has earned the right to hear our story and who has the capacity to respond with empathy. ~ Brene Brown

I must thank you for it all. I might not have gone but for you, and so have missed the finest study I ever came across: a study in scarlet, eh? Why shouldn't we use a little art jargon. There's the scarlet thread of murder running through the colourless skein of life, and our duty is to unravel it, and isolate it, and expose every inch of it. And now for lunch, and then for Norman Neruda. Her attack and her bowing are splendid. What's that little thing of Chopin's she plays so magnificently: Tra-la-la-lira-lira-lay. Leaning back in the cab, this amateur bloodhound carolled away like a lark while I meditated upon the many-sidedness of the human mind. ~ Arthur Conan Doyle

Peace is not just the absence of war. True peace depends upon creating the opportunity that makes life worth living. And to do that, we must confront the common enemies of human beings: nuclear weapons and poverty; ignorance and disease. ~ Barack Obama

The North Korean state was born at about the same time that Nineteen Eighty-Four was published, and one could almost believe that the holy father of the state, Kim Il Sung, was given a copy of the novel and asked if he could make it work in practice. Yet even Orwell did not dare to have it said that "Big Brother's" birth was attended by miraculous signs and portents - such as birds hailing the glorious event by singing in human words. ~ Christopher Hitchens

Let me simply state that it is wrong to regard any other human being, a priori, as an object, or an 'It.' This is so because each and every human being - you, every friend, every stranger, every foreigner - is precious. ~ M. Scott Peck

Seeing things a human shouldn't have to see makes us human. ~ Terry Pratchett

Your partner is your deepest mirror: do not expect them to change. Healing yourself, you heal your relationship. ~ Human Angels

Americans care more about the rights of animals than about what happens to us! ~ Joe Sacco

The human race is faced with a cruel choice: work or daytime twittering - anon Twitter has raised writing to a new low. ~ Samuel Goldwyn

It looks like the age of the mass is behind us and the age of the individual is upon us. The chasm that now exists between new people and old organizations is destroying economic value and inhibiting the emergence of a new chapter of capitalism aligned with the needs of this new society. The new purpose of commerce is to provide the tools, platforms, and relationships, digital or human, that enable individuals to live the lives they choose. ~ Shoshana Zuboff