Experimental Mapping Quotes

Despite the advancements of systematic experimental pipelines, literature-curated protein-interaction data continue to be the primary data for investigation of focused biological mechanisms. Notwithstanding the variable quality of curated interactions available in public databases, the impact of inspection bias on the ability of literature maps to provide insightful information remains equivocal. The problems posed by inspection bias extend beyond mapping of protein interactions to the development of pharmacological agents and other aspects of modern biomedicine. Essentially the same 10% of the proteome is being investigated today as was being investigated before the announcement of completion of the reference genome sequence. One way forward, at least with regard to interactome mapping, is to continue the transition toward systematic and relatively unbiased experimental interactome mapping. With continued advancement of systematic protein-interaction mapping efforts, the expectation is that interactome 'deserts', the zones of the interactome space where biomedical knowledge researchers simply do not look for interactions owing to the lack of prior knowledge, might eventually become more populated. Efforts at mapping protein interactions will continue to be instrumental for furthering biomedical research. ~ Joseph Loscalzo

Because for me to go fully experimental, it would turn into an artist book actually. And I'm not opposed to that. But I wanted to toy with the conventions of traditional narrative and sometimes to do that all the way, you have to actually utilize traditional narrative, I think - or it's one way to do it. ~ Porochista Khakpour

The word 'proof' should strictly only be used when we are dealing with deductive inferences.... Popper claimed that scientists only need to use deductive inferences.... So if a scientist is only interested in demonstrating that a given theory is false, she may be able to accomplish her goal without the use of inductive inferences.... When a scientist collects experimental data, her aim might be to show that a particular theory...is false. She will have to resort to inductive reasoning.... So Popper's attempt to show that science can get by without induction does not succeed. ~ Samir Okasha

The Harvard Law of Animal Behavior holds that under controlled experimental conditions of temperature, time, lighting, feeding, and training, the organism will behave as it damn well pleases. ~ Joel Garreau

I went into science, ending up with a Ph.D. in cell biology, but along the way I found out that experimental science involves many hours and days and nights of laboratory work, which is a lot like washing dishes, only a little more challenging. I was too impatient, and maybe a little too sloppy, for it. ~ Barbara Ehrenreich

Dreams are associated with a state called REM sleep, the abbreviation standing for rapid eye movement. The REM state is strongly correlated with sexual arousal. Experiments have been performed in which sleeping subjects are awakened whenever REM state emerges, while members of a control group are awakened just as often each night but not when they're dreaming. After some days, the control group is a little groggy, but the experimental group - the ones who are prevented from dreaming - is hallucinating in daytime. It's not that a few people with a particular abnormality can be made to hallucinate in this way; anyone is capable of hallucinations. ~ Carl Sagan

I am frequently astonished that it so often results in correct predictions of experimental results. ~ Murray Gell-Mann

US Energy Information Agency announced the availability of a new mapping tool that details the flood risk faced by our existing energy infrastructure. The map has icons located on sites like distribution terminals and power plants and allows users to overlay the existing flood risk on those sites. ~ Anonymous

He stands alone in hollow gloom, with the sound of his own breath whispering down unseen passages ahead and behind and to both sides, wondering how he stumbled into this blackest of all labyrinths.
He entered by choice. We all do. Whether we are mapping the heavens or skulking the lanes of the underworld, whether we are hunting the imprisoned fiend or have ourselves become the monster, whether we are searching for what is lost or hiding what must never be found, we all round that first corner by choice - and by then, we are lost.
You too. You must decide what is false and what is true, and what is true for me but not for you. We are wandering the mazes, all of us, and we cannot hope to escape until we learn to tell between what is real and what is real for someone else. There lies the madness, and the truth as well. ~ Troy Denning

I think I had actually served my apprenticeship as a writer of fiction by writing all those songs. I had already been through phases of autobiographical or experimental stuff. ~ Kazuo Ishiguro

The real reason why general relativity is widely accepted is because it made predictions that were borne out by experimental observations. ~ Brian Greene

I came into science fiction at a very good time, when the doors were getting thrown open to all kinds of more experimental writing, more literary writing, riskier writing. It wasn't all imitation Heinlein or Asimov. And of course, women were creeping in, infiltrating. Infesting the premises. ~ Ursula K. Le Guin

A major assumption that underlies this selection is that it is only within work that is progressive, experimental or avant-garde that staid, old-fashioned images and ideas about gender can be challenged and alternatives imagined. I have never seen a ballet performance that has not disappointed me. ~ Ramsay Burt

So you see, you have nothing to be afraid of.
Oh no, thought Otto, just squads of hired goons wandering around with experimental energy weapons. Nothing to be afraid of at all. ~ Mark Walden

If we take in our hand any volume; of divinity or school metaphysics, for instance; let us ask, Does it contain any abstract reasoning concerning quantity or number? No. Does it contain any experimental reasoning concerning matter of fact and existence? No. Commit it then to the flames: for it can contain nothing but sophistry and illusion. ~ David Hume

We think of enterprise architecture as the process we use for fully describing and mapping business functionality and business requirements and relating them to information systems requirements. ~ Tony Scott

The overwhelming majority of theories are rejected because they contain bad explanations, not because they fail experimental tests. ~ David Deutsch

Unlike men in the same position, women leaders have to continue to walk the fine line between appearing incompetent and nice and competent but cold. Experimental studies find that, unlike men, when they try to negotiate greater compensation they are disliked. When they try out intimidation tactics they are disliked. When they succeed in a male occupation they are disliked. When they fail to perform the altruistic acts that are optional for men, they are disliked. When they do go beyond the call of duty they are not, as men are, liked more for it. When they criticize, they are disparaged . Even when they merely offer an opinion, people look displeased. The perceptive reader will notice a certain pattern emerging. The same behavior that enhances his status simply makes her less popular. It's not hard to see that this makes the goal of getting ahead in the workplace distinctly more challenging for a woman. ~ Cordelia Fine

Science is defined in various ways, but today it is generally restricted to something which is experimental, which is repeatable, which can be predicted, and which is falsifiable. ~ Walter Lang

It was the best kind of class to have in the afternoon, an exercise in almost pure language, demanding nothing more than fractional consciousness since there wasn't the slightest hope of understanding what those poems were all about, and we drowsed and smiled, happy in our own little angel-infancy, snug in our Thamesian punt, and when the sonic belch of experimental jets went ripping across the desert we came close to applauding the symbolism; but a trembling applause it would have been, for we knew that it signaled the death of our drowsy England and the beginning of a new mortality, just months away now, the start of job, mate, child, desk, drink, sit, squat, quiver, die. ~ Don DeLillo

We had some really powerful technology - Atari always was a technology-driven company, and we were very keen on keeping the technological edge on everything. There's a whole bunch of things that we innovated. We made the first computer that did stamps or sprites, we did screen-mapping for the very first time, and a lot of stuff like that. ~ Nolan Bushnell

By clearly emphasizing all that was lacking in others, by mapping and raising to an art form the catalog of their flaws, Veblen's mother had inversely punched out a template for an ideal human being, and it was the unspoken assumption that Veblen would aspire to this template with all her might. "It's ~ Elizabeth Mckenzie

Far better an approximate answer to the right question, which is often vague, than the exact answer to the wrong question, which can always be made precise. ~ John Tukey

[ ... ] I'm going to have to be systematic about experimental eating so I know exactly what fatally poisons me. ~ Andrea K. Host

I get a very vague idea and - perhaps because I once was a journalist, or perhaps because that's what made me want to be a journalist - I go off and explore it for a bit, rather than mapping out a plot and then filling in the research. ~ Aminatta Forna

People are typically more comfortable talking with others in their own environment; being asked to come to a conference room to help a leadership-heavy team evaluate work flow can evoke understandable anxiety and make them feel like they are on a witness stand. It is much more effective to go to them. ~ Karen Martin

In the course of my stay there, I also showed how one could analyse the experimental kinetic curves for the reaction of haemoglobin with carbon dioxide or oxygen by simulations in the computer, and so fit the rate constants. ~ Aaron Klug

Places like the National Theatre or Sheffield, these great engines of theatre, make us cutting edge because they can be experimental. They can do plays that nobody else can afford to do in ways nobody else can afford to do. ~ Toby Stephens

Raymond collected expressions. He repeated them in experimental accents, as if learning a tune. He sounded like an Eighteenth Street Mexican when he said cuate, like a Logan Square cubano when he said comemierda. ~ Sebastian Rotella

Indeed, the most important part of engineering work-and also of other scientific work-is the determination of the method of attacking the problem, whatever it may be, whether an experimental investigation, or a theoretical calculation ... It is by the choice of a suitable method of attack, that intricate problems are reduced to simple phenomena, and then easily solved. ~ Charles Proteus Steinmetz

We need to welcome the experimental creativity that is always searching out new ways of singing the Gospel, and banish the fear that grips us when familiar music passes away. ~ Michael Adam Hamilton

Science is experimental, moving forward step-by-step, making trial and learning through success and failure. Is not this also the way of religion, and especially of the Christian religion? The writings of those who preach the religion have from the very beginning insisted that it is to be proved by experience. If a man is drawn towards honour and courage and endurance, justice, mercy, and charity, let him follow the way of Christ and find out for himself. No findings in science hinder him in that way. ~ William Henry Bragg

I'm experimental by nature ... always exploring my creativity. ~ Christina Aguilera

ArcGIS Online is the complete hosted GIS in the cloud, supporting mapping and apps. Additions to this component have included smart mapping, formal metadata, better administration, and high-performance geocoding. ~ Jack Dangermond

[I]t is necessary to insist upon this extraordinary but undeniable fact: experimental science has progressed thanks in great part to the work of men astoundingly mediocre, and even less than mediocre. That is to say, modern science, the root and symbol of our actual civilization, finds a place for the intellectually commonplace man and allows him to work therein with success. ~ Jose Ortega Y Gasset

My final remark to young women and men going into experimental science is that they should pay little attention to the speculative physics ideas of my generation. After all, if my generation has any really good speculative ideas, we will be carrying these ideas out ourselves. ~ Martin L. Perl

NASA gets to name their missions after gods and stuff, so why can't I? Henceforth, rover experimental missions will be "Sirius" missions. Get it? Dogs? Well if you don't, fuck you. ~ Andy Weir

The treatment of the indeterminacy principle as absolute and final can then be criticized as constituting an arbitrary restriction on scientific theories, since it does not follow from the quantum theory as such, but rather from the assumption of the unlimited validity of certain of its features, an assumption that can in no way ever be subjected to experimental proof. ~ David Bohm

Modeling the evolution of modularity became significantly easier after a kind of genetic variation was discovered by quantitative trait locus (QTL) mapping in the lab of James Cheverud at Washington University called 'relationship QTL' or r-QTL for short. An r-QTL is a genetic locus that affects the correlations between two quantitative traits (i.e. their variational relationship, and therefore, 'relationship' loci). Surprisingly, a large fraction of these so-mapped loci are also neutral with respect to the character mean. This means one can select on these 'neutral' r-QTLs without simultaneously changing the character mean in a certain way.
It was easy to show that differential directional selection on a character could easily lead a decrease in genetic correlation between characters. Of course, it is not guaranteed that each and every population has the right kind of r-QTL polymorphisms, nor is it yet clear what kind of genetic architecture allows for the existence of an r-QTL.
Nevertheless, these findings make it plausible that differential directional selection can enhance the genetic/variational individuality of traits and, thus, may play a role in the origin of evolutionary novelties by selecting for variational individuality.
It must be added, though, that there has been relatively little research in this area and that we will need to see more to determine whether we understand what is going on here, if anything. In particular, one difficulty is the math ~ Günter Wagner

I don't like it, and I'm sorry I ever had anything to do with it. ~ Erwin Schrodinger

Books written by boys are given very different treatment to those written by girls: they're even given very different covers. People also expect, in this YA-booming world, girls to be less experimental than boys: girls are achieving a lot of success, but they're confined. ~ Sarah Rees Brennan

The precision of hisskill places his work beyond the tentative and the experimental stage. He is continually searching and exploring both himself and his surroundings. and in this exploration of the realm of places, people and things, contrasts and relationships, Callahan is no respecter of conventional technical formula or code. His delicate sense of pattern is an integral part of his photography and not a thing by itself. ~ Edward Steichen

One is almost tempted to say ... at last I can almost see a bond. But that will never be, for a bond does not really exist at all: it is a most convenient fiction which, as we have seen, is convenient both to experimental and theoretical chemists. ~ Charles Coulson

Well, I think music for kids is never anything but experimental is it? ~ Fred Frith