Sam Kean Quotes

Mutations can arise anywhere in the genome, in gene DNA and noncoding DNA alike. But mutations to genes have bigger consequences: They can disable proteins and kill a creature.

Because our lungs regularly deal with carbon dioxide, they see nothing wrong with absorbing its cousin, SiO2, which can be fatal. Many dinosaurs might have died this way when a metropolis-sized asteroid or comet struck the earth 65 million years ago.

If certain bacteria, fungi, or algae inch across something made of copper, they absorb copper atoms, which disrupt their metabolism (human cells are unaffected). The microbes choke and die after a few hours.

But for years questions persisted about whether most cannibalism was religiously motivated and selective or culinary and routine. DNA suggests routine. Every known ethnic group worldwide has one of two genetic signatures that help our bodies fight off certain diseases that cannibals catch, especially mad-cow-like diseases that come from eating each other's brains. This defensive DNA almost certainly wouldn't have become fixed worldwide if it hadn't once been all too necessary.

Boron is carbon's neighbor on the periodic table, which means it can do a passable carbon impression and wriggle its way into the matrix of a diamond. But it has one fewer electron, so it can't quite form the same four perfect bonds.

The price of diamonds can vary greatly depending on size, cut, color, and other factors, including whether they have a history. But because of the rarity of blue boron diamonds, they often fetch more money than gems of similar quality.

It's often meaningless to talk about a genetic trait without also discussing the environment in which that trait appears. Sometimes, genes don't work at all until the environment awakens them.

The amygdala is indeed crucial for monitoring our environment and deciding what's worth getting worked up over. Once the amygdala determines this, however, it merely trips another circuit to actually produce the panic.

Negative experiences can wire neurons together, too.

The brain, which is plastic when young, must be exposed to certain sights early in life, or it will remain blind to those sights forever.

For more details about the Curies especially, see Sheilla Jones's wonderful book The Quantum Ten, an account of the surprisingly contentious and fractious early days of quantum mechanics, circa 1925.

Think of the most fussy science teacher you ever had. The one who docked your grade if the sixth decimal place in your answer was rounded incorrectly; who tucked in his periodic table T-shirt, corrected every student who said "weight" when he or she meant "mass", and made everyone, including himself, wear goggles even while mixing sugar water. Now try to imagine someone whom your teacher would hate for being anal-retentive. That is the kind of person who works for a bureau of standards and measurement.

Scientists have continued to tinker with different elements and have learned new ways to store and deliver energy.

Our evolution could have gone in different directions a lot of times. We could have gone extinct at some points. We might not have gotten our big brains, or Neanderthals might have made it while we did not.

You can think about this decoupling as the converse of neurons that fire together wire together. Here, neurons out of sync fail to link.

In a touch Buckland would have appreciated, this multipronged dispersal from Africa is sometimes called the Weak Garden of Eden theory. But this tale is actually better than the biblical version; we didn't lose Eden but learned to make other Edens across the world.

Brains, you see, vary a lot from person to person - they vary as much as faces do.

I think it's a natural human tendency, when you read something, you tend to read a lot of your prejudices into it. And neuroscience is like a lot of disciplines - it has fashions; things change.

The hippocampus helps record both types of memories initially, and it helps retain them for the medium term. The hippocampus also helps us access old personal memories in long-term storage in other parts of the brain.

Thirteen aluminum atoms grouped together in the right way do a killer bromine, the two entities indistinguishable in chemical reactions.

When it comes to the periodic table, the United States really blew its chance to make a name for itself. If you look over a map of all the elements named for cities, states, countries, and continents, it's not surprising that European locales dominate the map.

The most profound change that genetics brings about might not be scientific at all. It might be mental and even spiritual enrichment: a more expansive sense of who we humans are, existentially, and where we came from, and how we fit with other life on earth.

Lithium regulates the proteins that control the body's inner clock. This clock runs, oddly, on DNA, inside special neurons deep in the brain. Special proteins attach to people's DNA each morning, and after a fixed time they degrade and fall off. Sunlight resets the proteins over and over, so they hold on much longer. In fact, the proteins fall off only after darkness falls - at which point the brain should "notice" the bare DNA and stop producing stimulants. This process goes awry in manic-depressives because the proteins, despite the lack of sunlight, remain bound fast to their DNA. Their brains don't realize they should stop revving. Lithium helps cleave the proteins from DNA so people can wind down. Notice that sunlight still trumps lithium during the day and resets the proteins; it's only when the sunlight goes away at night that lithium helps DNA shake free. Far from being sunshine in a pill, then, lithium acts as "anti-sunlight." Neurologically, it undoes sunlight and thereby compresses the circadian clock back to twenty-four hours - preventing both the mania bubble from forming and the Black Tuesday crash into depression.

Despite its obscurity, probably no element on the periodic table has as colorful a history as antimony. Money, madness, poison, linguistics, charlatanism, sex - pretty much every theme that runs through the periodic table can be found in Element 51.

So while Pauling struggled with his model, Watson and Crick turned theirs inside out, so the negative phosphorus ions wouldn't touch. This gave them a sort of twisted ladder - the famed double helix.

Mendeleev, unlike the squeamish Meyer, had balls enough to predict that new elements would be dug up. Look harder, you chemists and geologists, he seemed to taunt, and you'll find them.

I was reading this story about these people who suffered from brain injuries, and then their behavior changed kind of drastically afterward, and I just said to myself, 'There's no way that that can possibly be true.'

All the elements other than hydrogen and helium make up just 0.04 percent of the universe. Seen from this perspective, the periodic system appears to be rather insignificant. But the fact remains that we live on the earth ... where the relative abundance of elements is quite different.

Confederate surgeons usually performed "circular" amputations. They made a 360-degree cut through the skin, then scrunched it up like a shirt cuff. After sawing through the muscle and bone, they inched the skin back down to wrap the stump. This method led to less scarring and infection. Union surgeons preferred "flap" amputations: doctors left two flaps of flesh hanging beside the wound to fold over after they'd sawed through. This method was quicker and provided a more comfortable stump for prosthetics. Altogether, surgeons lopped off 60,000 fingers, toes, hands, feet, and limbs during the war.

Those of us raised in modern cities tend to notice horizontal and vertical lines more quickly than lines at other orientations. In contrast, people raised in nomadic tribes do a better job noticing lines skewed at intermediate angles, since Mother Nature tends to work with a wider array of lines than most architects.

Genes are like the story, and DNA is the language that the story is written in.

The irony is too rich not to point out. When arranging the different human races in tiers, from just below the angels to just above the brutes, smug racialist scientists of the 1800s always equated black skin with 'subhuman' beasts like Neanderthals. But facts is facts: pure Nordic Europeans carry far more Neanderthal DNA than any modern African.

Whenever we read about people's lives, fictional or non-, we have to put ourselves into the minds of the characters. And honestly, my mind has never had to stretch so far, never had to work so hard, as it did to inhabit the minds of people with brain damage. They're recognizably human in so many ways, and yet still somehow off: Hamlet seems transparent next to H.M. But that's the power of stories, to reach across that divide.

Frontal lobes includes suppressing impulses from the parietal lobes, which are curious and capricious and, as the lobes most intimately involved with touch, want to explore everything tactilely. So when certain parts of the frontal lobe go kaput, the brain can no longer tamp down these parietal impulses, and the hand begins to flail and grab. (Neurologically, this flaring up of suppressed impulses resembles the "release" of the snout reflex in kuru victims.) And because the grasping impulse springs from the subconscious, the conscious brain can't always interrupt it and break the hand's grip. Hand-to-hand combat - with

One theme I ran into over and over while writing about the periodic table was the future of energy and the question of which element or elements will replace carbon as king.

Aluminum is the most common metal in the earth's crust, almost twice as abundant as iron. And one common class of aluminum minerals, collectively called alum, has been in use since at least Greek and Roman times.

Biologists summarize these hypothalamic duties as the "four F's" of animal behavior - feeding, fleeing, fighting, and, well, sexual congress.

Aluminium's sixty-year reign as the world's most precious substance was glorious, but soon an American chemist ruined everything.

Also unlike a planet, an electron - if excited by heat or light - can leap from its low-energy shell to an empty, high-energy shell. The electron cannot stay in the high-energy state for long, so it soon crashes back down. But this isn't a simple back-and-forth motion, because as it crashes, the electron jettisons energy by emitting light.

Yet they enjoy the high. In the surest sign that selenium actually makes them go mad, cattle grow addicted to locoweed despite its awful side effects and eat it to the exclusion of anything else. It's animal meth.

Similarly deadly to small wriggling cells, if a bit more quackish, is vanadium, element twenty-three, which also has a curious side effect in males: vanadium is the best spermicide ever devised. Most spermicides dissolve the fatty membrane that surrounds sperm cells, spilling their guts all over. Unfortunately, all cells have fatty membranes, so spermicides often irritate the lining of the vagina and make women susceptible to yeast infections. Not fun. Vanadium eschews any messy dissolving and simply cracks the crankshaft on the sperm's tails. The tails then snap off, leaving

Even if we never cure a single disease, the Human Genome Project and other ventures will have been worth it.

A long iron rod rocketed straight through the very forefront of Phineas Gage's brain. It's kind of an unusual part of the brain: you can suffer pretty severe injuries to it and often walk away from the injury. It's not a part of the brain that's necessarily vital for your biological self. But it is very important for personality.

Dr. Rush made patients ingest the solution until they drooled, and often people's teeth and hair fell out after weeks or months of continuous treatment. His "cure" no doubt poisoned or outright killed swaths of people whom yellow fever might have spared. Even so, having perfected his treatment in Philadelphia, ten years later he sent Meriwether and William off with some prepackaged samples. As a handy side effect, Dr. Rush's pills have enabled modern archaeologists to track down campsites used by the explorers. With the weird food and questionable water they encountered in the wild, someone in their party was always queasy, and to this day, mercury deposits dot the soil many places where the gang dug a latrine, perhaps after one of Dr. Rush's "Thunderclappers" had worked a little too well.

Sir Isaac Newton famously said that he had achieved everything by standing on the shoulders of giants - the scientific men whose findings he built upon. The same might be said about silicon. After germanium did all the work, silicon became an icon, and germanium was banished to periodic table obscurity.

Great literature remains great when it says new things to new generations, and the loops of a knot quite nicely parallel the contours and convolutions of Carroll's plot anyway.What's more, he probably would have been delighted at how this whimsical branch of math invaded the real world and became crucial to understanding our biology.

Cancer is really a DNA disease ... We have these certain genes that prevent our cells from growing out of control at the expense of the body. And it's a pretty good, robust system. But if a couple of these genes fail, then that's when cancer starts, and cells start growing out of control.

Medieval alchemists, despite their lust for gold, considered mercury the most potent and poetic substance in the universe. As a child, I would have agreed with them.

Carbon's eastern neighbor on the table, nitrogen, dresses up diamonds in pinks, yellows, oranges, and brownish tints known romantically as 'champagne.'

We crowned ourselves Homo sapiens, the wise ape, but Homo limbus might have been more apt.

All human beings are, in fact, born with dozens of mutations their parents lacked, and a few of those mutations could well be lethal if we didn't have two copies of every gene, so one can pick up the slack if the other malfunctions.

When you do the math and examine how much energy is produced per atomic union, you find that fusing anything to iron's twenty-six protons costs energy. That means post-ferric fusion* does an energy-hungry star no good. Iron is the final peal of a star's natural life.

Most people, even most doctors, learn that the placenta is a nice, tight seal that prevents anything in the mother's body from invading the fetus, and vice-versa. That's mostly true. But the placenta doesn't seal off the baby perfectly, and every so often, something slips across.

Germans at the time believed, a little oddly, that dyes killed germs by turning the germs' vital organs the wrong color.

If you had to sum up chemistry in one sentence, it might be this: Atoms need to have full shells of electrons to feel satisfied, and different elements steal, shed, or borrow different numbers of electrons to achieve a full shell.

Fruit fly scientists, God bless 'em, are the big exceptions. Morgan's team always picked sensibly descriptive names for mutant genes, like 'speck,' 'beaded,' 'rudimentary,' 'white,' and 'abnormal.' And this tradition continues today, as the names of most fruit fly genes eschew jargon and even shade whimsical… The 'turnip' gene makes flies stupid. 'Tudor' leaves males (as with Henry VIII) childless. 'Cleopatra' can kill flies when it interacts with another gene, 'asp.' 'Cheap date' leaves flies exceptionally tipsy after a sip of alcohol… And thankfully, this whimsy with names has inspired the occasional zinger in other areas of genetics… The backronym for the "POK erythroid myeloid ontogenic" gene in mice - 'pokemon' - nearly provoked a lawsuit, since the 'pokemon' gene (now known, sigh, as 'zbtb7') contributes to the spread of cancer, and the lawyers for the Pokemon media empire didn't want their cute little pocket monsters confused with tumors.

People fluent in two languages can lose either one after trauma, since first and second languages* draw on distinct neural circuits. Language deficits can even interfere with math. We seem to have a natural "number circuit" in the parietal lobe that handles comparisons and magnitudes - the basis of most arithmetic. But we learn some things (like the times tables) linguistically, by rote memorization. So if language goes kaput, so too will those linguistically based skills. More strikingly, some people who struggle to string even three words together can sing just fine.

So despite all the advances of neuroscience, all the fancy machines and illuminating insights, we still need our old, wet gray matter - the only place where emotion and reason come together and alchemize into what we call wisdom - to tell us how to act.

The amygdala is one of those brain structures that a lot of people know a little bit about, and there's a definite tendency to conflate the amygdala and the fear response itself - as if the amygdala, and the amygdala alone, 'causes' fear.

Everywhere in the universe, the periodic table has the same basic structure. Even if an alien civilization's table weren't plotted out in the castle-with-turrets shape we humans favor, their spiral or pyramidal or whatever-shaped periodic table would naturally pause after 118 elements.

Microchimeric sharing means that, even if the mother loses a child, she'll have a small memento of him or her secreted away inside her. Similarly, a bit of our mothers live on in all of us no matter how long ago Mom died.

Even a good, inveterate atheist like physicist Richard Feynman once said of the fine structure constant, "All good theoretical physicists put this number up on their wall and worry about it…. It's one of the greatest damn mysteries of physics: a magic number that comes to us with no understanding by man. You might say the 'hand of God' wrote that number, and we don't know how He pushed His pencil.

(Rutherford himself was fond of saying, "In science, there is only physics; all the rest is stamp collecting" - words

Most mutations involve typos: Something bumps a cell's elbow as it's copying DNA, and the wrong letter appears in a triplet - CAG becomes CCG.

English philosopher Bertrand Russell, another prominent twentieth-century pacifist, once used those medicinal facts about iodine to build a case against the existence of immortal souls. "The energy used in thinking seems to have a chemical origin ... ," he wrote. "For instance, a deficiency of iodine will turn a clever man into an idiot. Mental phenomena seem to be bound up with material structure." In other words, iodine made Russell realize that reason and emotions and memories depend on material conditions in the brain. He saw no way to separate the "soul" from the body, and concluded that the rich mental life of human beings, the source of all their glory and much of their woe, is chemistry through and through.

For a long time, I kept an eye out for element eighty at school and in books, as you might watch for a childhood friend's name

The body tends to treat elements in the same column of the periodic table as equivalents.

Many different elements can form isomers, but only a few elements on the periodic table, like hafnium, can form isomers that last more than fractions of a second - and might therefore be turned into weapons.

For his part, Mendeleev scanned Lecoq de Boisbaudran's data on gallium and told the experimentalist, with no justification, that he must have measured something wrong, because the density and weight of gallium differed from Mendeleev's predictions. This betrays a flabbergasting amount of gall, but as science philosopher-historian Eric Scerri put it, Mendeleev always "was willing to bend nature to fit his grand philosophical scheme." The only difference between Mendeleev and crackpottery is that Mendeleev was right: Lecoq de Boisbaudran soon retracted his data and published results that corroborated Mendeleev's predictions.

If stem cells divide equally, so both daughter cells look more or less the same, each one becomes another stem cell. If the split is unequal, neurons form prematurely.

The amygdala plays a crucial role in processing fear, and minus her two amygdalae, S.M. became unflappable. Studies of her are actually a hoot to read, since they basically consist of scientists concocting ever-more-elaborate ways of trying to scare her.

In these days before antiseptics, doctors themselves also suffered high mortality rates. Florence Nightingale, a nurse during the Crimean War (1853-1856), watched one particularly inept surgeon cut both himself and, somehow, a bystander while blundering about during an amputation. Both men contracted an infection and died, as did the patient. Nightingale commented that it was the only surgery she'd ever seen with 300 percent mortality.

Cathedrals of Science: The Personalities and Rivalries That Made Modern Chemistry

In some sense, what you might have suspected from the first day of high-school chemistry is true: The periodic table is a colossal waste of time. Nine out of every 10 atoms in the universe are hydrogen, the first element and the major constituent of stars. The other 10 percent of all atoms are helium.

Geneticists in the early 1900s believed that nature - in an effort to avoid wasting precious space within chromosomes - would pack as many genes into each chromosome as possible.

Your body thinks radium is a great thing to pack into bone - where it kills some cells outright and scrambles the DNA of others, causing problems like cancer.

Atoms of Element 118 fill an outer shell with electrons, creating a special type of element called a noble gas. Noble gases are natural turning points on the table, ending one row and pointing to the next.

Despite the earnest belief of most of his fans, Einstein did not win his Nobel Prize for the theory of relativity, special or general. He won for explaining a strange effect in quantum mechanics, the photoelectric effect. His solution provided the first real evidence that quantum mechanics wasn't a crude stopgap for justifying anomalous experiments, but actually corresponds to reality. And the fact that Einstein came up with it is ironic for two reasons. One, as he got older and crustier, Einstein came to distrust quantum mechanics. Its statistical and deeply probabilistic nature sounded too much like gambling to him, and it prompted him to object that "God does not play dice with the universe." He was wrong, and it's too bad that most people have never heard the rejoinder by Niels Bohr: "Einstein! Stop telling God what to do.

Entrepreneurs in the United States and Europe finally figured out how to separate aluminum from minerals cheaply and also how to produce it on an industrial scale.

B2FH traces these various fusion reactions and explains the recipe for producing everything up to iron: it's nothing less than evolution for elements.

Today, just two generations on, the Monte Carlo method (in various forms) so dominates some fields that many young scientists don't realize how thoroughly they've departed from traditional theoretical or experimental science.

Hat manufacturers once used a bright orange mercury wash to separate fur from pelts, and the common hatters who dredged around in the steamy vats, like the mad one in Alice in Wonderland, gradually lost their hair and wits.

We human beings are humane in part because we can look beyond our biology.

Before the Human Genome Project, most scientists assumed, based on our complex brains and behaviors, that humans must have around 100,000 genes; some estimates went as high as 150,000.

We know that genes shape human cultures and human societies: The DNA we inherited from our ancestors makes certain foods taste better, affects the way we care for children, influences what colors we find vibrant, and contributes to our love of socializing, among other examples.

Something funny certainly happens when palladium and platinum come into contact with hydrogen gas; it's one of the great mysteries still waiting to be solved on the periodic table. But it's quite a leap from 'something funny' to cold fusion.

S-A-T-O-R
A-R-E-P-O
T-E-N-E-T
O-P-E-R-A
R-O-T-A-S

The palindrome means something like "The farmer Arepo works with his plow," with rotas, literally "wheels," referring to the back-and-forth motion that plows make as they till. This "magic square" has delighted enigmatologists for centuries ... The magic square also reportedly kept away the devil, who traditionally (so said the church) got confused when he read palindromes.

The mutated Marfan gene creates a defective version of fibrillin, a protein that provides structural support for soft tissues like blood vessels. Marfan victims often die young, in fact, after their aortas grow threadbare and rupture.

The inability to trace DNA to actual diseases has serious consequences. As does the opposite problem - not being able to trace diseases back to DNA.

The idea of critical windows extends beyond just vision, of course: almost every system in the brain has a critical window when it needs to experience certain stimuli, or it won't get wired up properly. The most obvious example is language: if you don't learn a language early on, it's nigh impossible to become truly fluent.

A fully plastic brain learns everything and remembers nothing.

When first presented with the jumble of the periodic table, I scanned for mercury and couldn't find it. It is there - between gold, which is also dense and soft, and thallium, which is also poisonous. But the symbol for mercury, Hg, consists of two letters that don't even appear in its name.

So if big enough droplets fell far enough fast enough, someone floating right near the metallic hydrogen layer inside Jupiter maybe, just maybe, could have looked up into its cream and orange sky and seen the most spectacular show ever
fireworks lighting up the Jovian night with a trillion streaks of brilliant crimson, what scientists call neon rain.

After about 1940, scientists generally stopped looking for elements in nature. Instead, they had to create them by smashing smaller atoms together.

No element gets people telling crazy stories like mercury does. People have told me tales about pharmacists waxing floors with mercury, mothers rubbing it into babies' skin to kill germs, and 10-year-olds coating dimes in it to make them shine, then blithely carrying them around in their pockets.

Furthermore, because silicon packs on more protons than carbon, it's bulkier, like carbon with fifty extra pounds. Sometimes that's not a big deal. Silicon might substitute adequately for carbon in the Martian equivalent of fats or proteins. But carbon also contorts itself into ringed molecules we call sugars. Rings are states of high-tension- which means they store lots of energy-and silicon just isn't supple enough to bend into the right position to form rings. In a related problem, silicon atoms cannot squeeze their electrons into tight spaces for double bonds, which appear in virtually every complicated biochemical.

Even fictional characters sometimes receive unwarranted medical opinions. Doctors have diagnosed Ebenezer Scrooge with OCD, Sherlock Holmes with autism, and Darth Vader with borderline personality disorder.

In 'The Violinist's Thumb,' I talk about the poignancy of cells leaking across the placenta into both the mother and the child.

You're not supposed to interject feelings into science, but part of the reason it's so fascinating that we're 8 percent (or more) fossilized virus is that it's so creepy that we're 8 percent (or more) fossilized virus.

People adored Element 13's color and luster, which reminded them of the sparkle of gold and silver - a brand-new precious metal. In fact, aluminum became more precious than gold and silver in the 19th century because it was harder to obtain.