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According to the dictionary entry on extracellular matrix in the Biology Online resource, biologists have recently become aware of the fact that an organism's environment or substrate (e.g. extracellular matrix) can influence the behavior of cells quite markedly, possibly even more significantly than DNA in the development of complex organisms. The removal of cells from their usual environment to another environment can have far-reaching effects.
Art in the twenty-first century may come to constitute a form of mediation between human and post-human consciousness, just as in past cultures it has been used to mediate between mankind and the gods.
To say that humans are composed of machines is not to say that we are merely machines. Humans are dignified machines. We are (so far) the most extropic, most complex product of billions of years of evolution.
No more gods, no more faith, no more timid holding back. Let us blast out of our old forms, our ignorance, our weakness, and our mortality. The future belongs to posthumanity.
We have achieved two of the three alchemists' dreams: We have transmuted the elements and learned to fly. Immortality is next.
The "I" is a grammatical fiction (Nietzsche). There are bundles of impressions but no underlying self (Hume). There is no survival because there is no person (Buddha, Parfit).